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Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.
Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J. Saura CA, et al. Among authors: shen j. J Neurosci. 2005 Jul 20;25(29):6755-64. doi: 10.1523/JNEUROSCI.1247-05.2005. J Neurosci. 2005. PMID: 16033885 Free PMC article.
Indirect regulation of presenilins in CREB-mediated transcription.
Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ 3rd, Shen J. Watanabe H, et al. Among authors: shen j. J Biol Chem. 2009 May 15;284(20):13705-13713. doi: 10.1074/jbc.M809168200. Epub 2009 Mar 16. J Biol Chem. 2009. PMID: 19289467 Free PMC article.
Presenilins are essential for regulating neurotransmitter release.
Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J. Zhang C, et al. Among authors: shen j. Nature. 2009 Jul 30;460(7255):632-6. doi: 10.1038/nature08177. Nature. 2009. PMID: 19641596 Free PMC article.
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