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Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Goel P, Jumpertz T, Mikles DC, Tichá A, Nguyen MTN, Verhelst S, Hubalek M, Johnson DC, Bachovchin DA, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Goel P, et al. Among authors: ogorek i. Biochemistry. 2017 Dec 26;56(51):6713-6725. doi: 10.1021/acs.biochem.7b01066. Epub 2017 Dec 12. Biochemistry. 2017. PMID: 29185711 Free PMC article.
The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, Wiltfang J, Becker-Pauly C, Beher D, Pietrzik CU, Fraering PC, Wirths O, Weggen S. Walter S, et al. Among authors: ogorek i. Acta Neuropathol. 2019 Feb;137(2):239-257. doi: 10.1007/s00401-018-1929-5. Epub 2018 Nov 13. Acta Neuropathol. 2019. PMID: 30426203
Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
Kurth V, Ogorek I, Münch C, Lopez-Rios J, Ousson S, Lehmann S, Nieweg K, Roebroek AJM, Pietrzik CU, Beher D, Weggen S. Kurth V, et al. Among authors: ogorek i. J Biol Chem. 2023 Aug;299(8):104997. doi: 10.1016/j.jbc.2023.104997. Epub 2023 Jun 30. J Biol Chem. 2023. PMID: 37394008 Free PMC article.
Blood platelets in the progression of Alzheimer's disease.
Gowert NS, Donner L, Chatterjee M, Eisele YS, Towhid ST, Münzer P, Walker B, Ogorek I, Borst O, Grandoch M, Schaller M, Fischer JW, Gawaz M, Weggen S, Lang F, Jucker M, Elvers M. Gowert NS, et al. Among authors: ogorek i. PLoS One. 2014 Feb 28;9(2):e90523. doi: 10.1371/journal.pone.0090523. eCollection 2014. PLoS One. 2014. PMID: 24587388 Free PMC article.
Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro.
Suwala AK, Koch K, Rios DH, Aretz P, Uhlmann C, Ogorek I, Felsberg J, Reifenberger G, Köhrer K, Deenen R, Steiger HJ, Kahlert UD, Maciaczyk J. Suwala AK, et al. Among authors: ogorek i. Oncotarget. 2018 Apr 27;9(32):22703-22716. doi: 10.18632/oncotarget.25210. eCollection 2018 Apr 27. Oncotarget. 2018. PMID: 29854309 Free PMC article.