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Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau.
Starbuck K, Al-Alem L, Eavarone DA, Hernandez SF, Bellio C, Prendergast JM, Stein J, Dransfield DT, Zarrella B, Growdon WB, Behrens J, Foster R, Rueda BR. Starbuck K, et al. Among authors: prendergast jm. Oncotarget. 2018 May 1;9(33):23289-23305. doi: 10.18632/oncotarget.25289. eCollection 2018 May 1. Oncotarget. 2018. PMID: 29796189 Free PMC article.
Production of a mouse monoclonal IgM antibody that targets the carbohydrate Thomsen-nouveau cancer antigen resulting in in vivo and in vitro tumor killing.
Trabbic KR, Kleski KA, Shi M, Bourgault JP, Prendergast JM, Dransfield DT, Andreana PR. Trabbic KR, et al. Among authors: prendergast jm. Cancer Immunol Immunother. 2018 Sep;67(9):1437-1447. doi: 10.1007/s00262-018-2206-0. Epub 2018 Jul 20. Cancer Immunol Immunother. 2018. PMID: 30030557 Free PMC article.
Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma.
Eavarone DA, Al-Alem L, Lugovskoy A, Prendergast JM, Nazer RI, Stein JN, Dransfield DT, Behrens J, Rueda BR. Eavarone DA, et al. Among authors: prendergast jm. PLoS One. 2018 Jul 27;13(7):e0201314. doi: 10.1371/journal.pone.0201314. eCollection 2018. PLoS One. 2018. PMID: 30052649 Free PMC article.
Sialyl-Tn serves as a potential therapeutic target for ovarian cancer.
Al-Alem L, Prendergast JM, Clark J, Zarrella B, Zarrella DT, Hill SJ, Growdon WB, Pooladanda V, Spriggs DR, Cramer D, Elias KM, Nazer RI, Skates SJ, Behrens J, Dransfield DT, Rueda BR. Al-Alem L, et al. Among authors: prendergast jm. J Ovarian Res. 2024 Apr 2;17(1):71. doi: 10.1186/s13048-024-01397-1. J Ovarian Res. 2024. PMID: 38566237 Free PMC article.
26 results