Okabe T - Search Results

1

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.

Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H. Tsuburaya N, et al. Among authors: okabe t. Nat Commun. 2018 Jul 10;9(1):2668. doi: 10.1038/s41467-018-05127-2. Nat Commun. 2018. PMID: 29991716 Free PMC article.

2

Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors.

Kawaguchi M, Terai T, Utata R, Kato M, Tsuganezawa K, Tanaka A, Kojima H, Okabe T, Nagano T. Kawaguchi M, et al. Among authors: okabe t. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3752-5. doi: 10.1016/j.bmcl.2008.05.040. Epub 2008 May 16. Bioorg Med Chem Lett. 2008. PMID: 18524589

3

A fluorescence correlation spectroscopy-based assay for fragment screening of slowly inhibiting protein-peptide interaction inhibitors.

Mikuni J, Kato M, Taruya S, Tsuganezawa K, Mori M, Ogawa N, Honma T, Yokoyama S, Kojima H, Okabe T, Nagano T, Tanaka A. Mikuni J, et al. Among authors: okabe t. Anal Biochem. 2010 Jul 1;402(1):26-31. doi: 10.1016/j.ab.2010.03.019. Epub 2010 Mar 15. Anal Biochem. 2010. PMID: 20298671

4

A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening.

Kawaguchi M, Okabe T, Terai T, Hanaoka K, Kojima H, Minegishi I, Nagano T. Kawaguchi M, et al. Among authors: okabe t. Chemistry. 2010 Dec 3;16(45):13479-86. doi: 10.1002/chem.201001077. Chemistry. 2010. PMID: 20938933

5

Identification of novel ASK1 inhibitors using virtual screening.

Okamoto M, Saito N, Kojima H, Okabe T, Takeda K, Ichijo H, Furuya T, Nagano T. Okamoto M, et al. Among authors: okabe t. Bioorg Med Chem. 2011 Jan 1;19(1):486-9. doi: 10.1016/j.bmc.2010.11.004. Epub 2010 Nov 12. Bioorg Med Chem. 2011. PMID: 21134755

6

Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity.

Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H. Arita M, et al. Among authors: okabe t. J Virol. 2011 Mar;85(5):2364-72. doi: 10.1128/JVI.02249-10. Epub 2010 Dec 22. J Virol. 2011. PMID: 21177810 Free PMC article.

7

A dual inhibitor against prolyl isomerase Pin1 and cyclophilin discovered by a novel real-time fluorescence detection method.

Mori T, Hidaka M, Lin YC, Yoshizawa I, Okabe T, Egashira S, Kojima H, Nagano T, Koketsu M, Takamiya M, Uchida T. Mori T, et al. Among authors: okabe t. Biochem Biophys Res Commun. 2011 Mar 18;406(3):439-43. doi: 10.1016/j.bbrc.2011.02.066. Epub 2011 Feb 17. Biochem Biophys Res Commun. 2011. PMID: 21333629

8

Virtual screening and further development of novel ALK inhibitors.

Okamoto M, Kojima H, Saito N, Okabe T, Masuda Y, Furuya T, Nagano T. Okamoto M, et al. Among authors: okabe t. Bioorg Med Chem. 2011 May 15;19(10):3086-95. doi: 10.1016/j.bmc.2011.04.008. Epub 2011 Apr 7. Bioorg Med Chem. 2011. PMID: 21515061

9

Fluorescence probe for lysophospholipase C/NPP6 activity and a potent NPP6 inhibitor.

Kawaguchi M, Okabe T, Okudaira S, Hanaoka K, Fujikawa Y, Terai T, Komatsu T, Kojima H, Aoki J, Nagano T. Kawaguchi M, et al. Among authors: okabe t. J Am Chem Soc. 2011 Aug 10;133(31):12021-30. doi: 10.1021/ja201028t. Epub 2011 Jul 18. J Am Chem Soc. 2011. PMID: 21721554

10

A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.

Tsuganezawa K, Watanabe H, Parker L, Yuki H, Taruya S, Nakagawa Y, Kamei D, Mori M, Ogawa N, Tomabechi Y, Handa N, Honma T, Yokoyama S, Kojima H, Okabe T, Nagano T, Tanaka A. Tsuganezawa K, et al. Among authors: okabe t. J Mol Biol. 2012 Mar 30;417(3):240-52. doi: 10.1016/j.jmb.2012.01.036. Epub 2012 Jan 30. J Mol Biol. 2012. PMID: 22306408

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