Mo M - Search Results

1

Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice.

Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D. Mo M, et al. J Med Chem. 2018 Sep 27;61(18):8241-8254. doi: 10.1021/acs.jmedchem.8b00727. Epub 2018 Sep 13. J Med Chem. 2018. PMID: 30074791

2

Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine.

Qi XY, Cao Y, Li YL, Mo MG, Zhou L, Ye DY. Qi XY, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3511-3515. doi: 10.1016/j.bmcl.2017.05.074. Epub 2017 May 25. Bioorg Med Chem Lett. 2017. PMID: 28619536

3

2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity.

Lou B, Liu Q, Hou J, Kabir I, Liu P, Ding T, Dong J, Mo M, Ye D, Chen Y, Bui HH, Roth K, Cao Y, Jiang XC. Lou B, et al. Among authors: mo m. J Biol Chem. 2018 Nov 23;293(47):18328-18336. doi: 10.1074/jbc.RA118.005904. Epub 2018 Oct 10. J Biol Chem. 2018. PMID: 30305392 Free PMC article.

4

Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor.

Li Y, Huang T, Lou B, Ye D, Qi X, Li X, Hu S, Ding T, Chen Y, Cao Y, Mo M, Dong J, Wei M, Chu Y, Li H, Jiang XC, Cheng N, Zhou L. Li Y, et al. Among authors: mo m. Eur J Med Chem. 2019 Feb 1;163:864-882. doi: 10.1016/j.ejmech.2018.12.028. Epub 2018 Dec 13. Eur J Med Chem. 2019. PMID: 30580239

5

Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.

Deng Y, Hu JC, He SH, Lou B, Ding TB, Yang JT, Mo MG, Ye DY, Zhou L, Jiang XC, Yu K, Dong JB. Deng Y, et al. Acta Pharmacol Sin. 2021 Jan;42(1):149-159. doi: 10.1038/s41401-020-0419-1. Epub 2020 May 25. Acta Pharmacol Sin. 2021. PMID: 32451413 Free PMC article.

6

A selective sphingomyelin synthase 2 inhibitor ameliorates diet induced insulin resistance via the IRS-1/Akt/GSK-3β signaling pathway.

Huang Y, Huang T, Zhen X, Li Y, Mo M, Ye D, Cheng N. Huang Y, et al. Among authors: mo m. Pharmazie. 2019 Sep 1;74(9):553-558. doi: 10.1691/ph.2019.9310. Pharmazie. 2019. PMID: 31484596

7

Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule.

Zhang X, Jiang L, Huang K, Fang C, Li J, Yang J, Li H, Ruan X, Wang P, Mo M, Wu P, Xu Y, Peng C, Uesugi M, Ye D, Yu FX, Zhou L. Zhang X, et al. Among authors: mo m. ACS Chem Biol. 2020 Mar 20;15(3):632-639. doi: 10.1021/acschembio.9b00962. Epub 2020 Feb 24. ACS Chem Biol. 2020. PMID: 32069008

8

Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors.

Chen X, Xu W, Wang K, Mo M, Zhang W, Du L, Yuan X, Xu Y, Wang Y, Shen J. Chen X, et al. Among authors: mo m. J Med Chem. 2015 Nov 12;58(21):8529-41. doi: 10.1021/acs.jmedchem.5b01024. Epub 2015 Oct 28. J Med Chem. 2015. PMID: 26479945

9

Correction: 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity.

Lou B, Liu Q, Hou J, Kabir I, Liu P, Ding T, Dong J, Mo M, Ye D, Chen Y, Bui HH, Roth K, Cao Y, Jiang XC. Lou B, et al. Among authors: mo m. J Biol Chem. 2019 May 31;294(22):8716. doi: 10.1074/jbc.AAC119.009289. J Biol Chem. 2019. PMID: 31152097 Free PMC article. No abstract available.

10

Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema.

Chen X, Wang K, Xu W, Ma Q, Chen M, Du L, Mo M, Wang Y, Shen J. Chen X, et al. Among authors: mo m. J Med Chem. 2016 Mar 24;59(6):2674-87. doi: 10.1021/acs.jmedchem.5b01930. Epub 2016 Mar 8. J Med Chem. 2016. PMID: 26927682

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