Gooderham NJ - Search Results

1

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid.

Akingbasote JA, Foster AJ, Jones HB, David R, Gooderham NJ, Wilson ID, Kenna JG. Akingbasote JA, et al. Among authors: gooderham nj. Toxicol Res (Camb). 2016 Nov 9;6(1):81-88. doi: 10.1039/c6tx00376a. eCollection 2017 Jan 1. Toxicol Res (Camb). 2016. PMID: 30090479 Free PMC article.

2

Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

David RM, Gooderham NJ. David RM, et al. Among authors: gooderham nj. Toxicol Res (Camb). 2015 Nov 18;5(1):312-317. doi: 10.1039/c5tx00343a. eCollection 2016 Jan 1. Toxicol Res (Camb). 2015. PMID: 30090347 Free PMC article.

3

The selective cytotoxicity of the alkenyl glucosinolate hydrolysis products and their presence in Brassica vegetables.

Kadir NH, David R, Rossiter JT, Gooderham NJ. Kadir NH, et al. Among authors: gooderham nj. Toxicology. 2015 Aug 6;334:59-71. doi: 10.1016/j.tox.2015.06.002. Epub 2015 Jun 9. Toxicology. 2015. PMID: 26066520 Free article.

4

Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer.

Malik DE, David RM, Gooderham NJ. Malik DE, et al. Among authors: gooderham nj. Arch Toxicol. 2018 Apr;92(4):1639-1655. doi: 10.1007/s00204-018-2160-9. Epub 2018 Jan 23. Arch Toxicol. 2018. PMID: 29362861 Free PMC article.

5

Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells.

Malik DE, David RM, Gooderham NJ. Malik DE, et al. Among authors: gooderham nj. Arch Toxicol. 2018 Oct;92(10):3223-3239. doi: 10.1007/s00204-018-2291-z. Epub 2018 Aug 24. Arch Toxicol. 2018. PMID: 30155724 Free PMC article.

6

Dose-dependent synergistic and antagonistic mutation responses of binary mixtures of the environmental carcinogen benzo[a]pyrene with food-derived carcinogens.

David RM, Gooderham NJ. David RM, et al. Among authors: gooderham nj. Arch Toxicol. 2018 Dec;92(12):3459-3469. doi: 10.1007/s00204-018-2319-4. Epub 2018 Sep 26. Arch Toxicol. 2018. PMID: 30259071 Free article.

7

Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells.

Malik DE, David RM, Gooderham NJ. Malik DE, et al. Among authors: gooderham nj. Arch Toxicol. 2019 Oct;93(10):3005-3020. doi: 10.1007/s00204-019-02558-8. Epub 2019 Sep 12. Arch Toxicol. 2019. PMID: 31515600 Free article.

8

Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens.

David R, Ebbels T, Gooderham N. David R, et al. Environ Health Perspect. 2016 Jan;124(1):88-96. doi: 10.1289/ehp.1409557. Epub 2015 Jun 19. Environ Health Perspect. 2016. PMID: 26091049 Free PMC article.

9

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.

Patel SA, Bhambra U, Charalambous MP, David RM, Edwards RJ, Lightfoot T, Boobis AR, Gooderham NJ. Patel SA, et al. Among authors: gooderham nj. Br J Cancer. 2014 Dec 9;111(12):2287-96. doi: 10.1038/bjc.2014.540. Epub 2014 Oct 21. Br J Cancer. 2014. PMID: 25333344 Free PMC article.

10

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis.

Sathyapalan T, David R, Gooderham NJ, Atkin SL. Sathyapalan T, et al. Among authors: gooderham nj. Sci Rep. 2015 Nov 19;5:16890. doi: 10.1038/srep16890. Sci Rep. 2015. PMID: 26582398 Free PMC article.

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