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Linaclotide improves gastrointestinal transit in cystic fibrosis mice by inhibiting sodium/hydrogen exchanger 3.
McHugh DR, Cotton CU, Moss FJ, Vitko M, Valerio DM, Kelley TJ, Hao S, Jafri A, Drumm ML, Boron WF, Stern RC, McBennett K, Hodges CA. McHugh DR, et al. Among authors: cotton cu. Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G868-G878. doi: 10.1152/ajpgi.00261.2017. Epub 2018 Aug 17. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 30118317 Free PMC article.
CFTR inhibition mimics the cystic fibrosis inflammatory profile.
Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB. Perez A, et al. Among authors: cotton cu. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L383-95. doi: 10.1152/ajplung.00403.2005. Epub 2006 Aug 18. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 16920886 Free article.
78 results