Barkhem T - Search Results

1

Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.

Jacobson PB, von Geldern TW, Ohman L, Osterland M, Wang J, Zinker B, Wilcox D, Nguyen PT, Mika A, Fung S, Fey T, Goos-Nilsson A, Grynfarb M, Barkhem T, Marsh K, Beno DW, Nga-Nguyen B, Kym PR, Link JT, Tu N, Edgerton DS, Cherrington A, Efendic S, Lane BC, Opgenorth TJ. Jacobson PB, et al. Among authors: barkhem t. J Pharmacol Exp Ther. 2005 Jul;314(1):191-200. doi: 10.1124/jpet.104.081257. Epub 2005 Mar 22. J Pharmacol Exp Ther. 2005. PMID: 15784656

2

Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.

von Geldern TW, Tu N, Kym PR, Link JT, Jae HS, Lai C, Apelqvist T, Rhonnstad P, Hagberg L, Koehler K, Grynfarb M, Goos-Nilsson A, Sandberg J, Osterlund M, Barkhem T, Höglund M, Wang J, Fung S, Wilcox D, Nguyen P, Jakob C, Hutchins C, Färnegårdh M, Kauppi B, Ohman L, Jacobson PB. von Geldern TW, et al. Among authors: barkhem t. J Med Chem. 2004 Aug 12;47(17):4213-30. doi: 10.1021/jm0400045. J Med Chem. 2004. PMID: 15293993

3

Molecular mechanisms, physiological consequences and pharmacological implications of estrogen receptor action.

Barkhem T, Nilsson S, Gustafsson JA. Barkhem T, et al. Am J Pharmacogenomics. 2004;4(1):19-28. doi: 10.2165/00129785-200404010-00003. Am J Pharmacogenomics. 2004. PMID: 14987119 Review.

4

Transcriptional synergism on the pS2 gene promoter between a p160 coactivator and estrogen receptor-alpha depends on the coactivator subtype, the type of estrogen response element, and the promoter context.

Barkhem T, Haldosén LA, Gustafsson JA, Nilsson S. Barkhem T, et al. Mol Endocrinol. 2002 Nov;16(11):2571-81. doi: 10.1210/me.2002-0051. Mol Endocrinol. 2002. PMID: 12403846

5

pS2 Gene expression in HepG2 cells: complex regulation through crosstalk between the estrogen receptor alpha, an estrogen-responsive element, and the activator protein 1 response element.

Barkhem T, Haldosén LA, Gustafsson JA, Nilsson S. Barkhem T, et al. Mol Pharmacol. 2002 Jun;61(6):1273-83. doi: 10.1124/mol.61.6.1273. Mol Pharmacol. 2002. PMID: 12021387

6

Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists.

Barkhem T, Carlsson B, Nilsson Y, Enmark E, Gustafsson J, Nilsson S. Barkhem T, et al. Mol Pharmacol. 1998 Jul;54(1):105-12. doi: 10.1124/mol.54.1.105. Mol Pharmacol. 1998. PMID: 9658195

7

Characterization of the "estrogenicity" of tamoxifen and raloxifene in HepG2 cells: regulation of gene expression from an ERE controlled reporter vector versus regulation of the endogenous SHBG and PS2 genes.

Barkhem T, Andersson-Ross C, Höglund M, Nilsson S. Barkhem T, et al. J Steroid Biochem Mol Biol. 1997 May;62(1):53-64. doi: 10.1016/s0960-0760(97)00017-4. J Steroid Biochem Mol Biol. 1997. PMID: 9366498

8

Comparative studies of rat recombinant purple acid phosphatase and bone tartrate-resistant acid phosphatase.

Ek-Rylander B, Barkhem T, Ljusberg J, Ohman L, Andersson KK, Andersson G. Ek-Rylander B, et al. Among authors: barkhem t. Biochem J. 1997 Jan 15;321 ( Pt 2)(Pt 2):305-11. doi: 10.1042/bj3210305. Biochem J. 1997. PMID: 9020859 Free PMC article.

9

Cardiac nuclear hormone receptor mRNA in heart failure in man.

Sylvén C, Jansson E, Sotonyi P, Waagstein F, Barkhem T, Brönnegård M. Sylvén C, et al. Among authors: barkhem t. Life Sci. 1996;59(22):1917-22. doi: 10.1016/s0024-3205(96)00539-5. Life Sci. 1996. PMID: 8950289

10

Downregulation of thyroid hormone receptor subtype mRNA levels by amiodarone during catecholamine stress in vitro.

Drvota V, Brönnegård M, Hägglad J, Barkhem T, Sylvén C. Drvota V, et al. Among authors: barkhem t. Biochem Biophys Res Commun. 1995 Jun 26;211(3):991-6. doi: 10.1006/bbrc.1995.1909. Biochem Biophys Res Commun. 1995. PMID: 7598731

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