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Modeling Alzheimer's disease in progeria mice. An age-related concept.
Sharma K, Darvas M, Keene CD, Niedernhofer LJ, Ladiges W. Sharma K, et al. Among authors: niedernhofer lj. Pathobiol Aging Age Relat Dis. 2018 Oct 4;8(1):1524815. doi: 10.1080/20010001.2018.1524815. eCollection 2018. Pathobiol Aging Age Relat Dis. 2018. PMID: 30319737 Free PMC article.
Molecular pathology endpoints useful for aging studies.
Niedernhofer LJ, Kirkland JL, Ladiges W. Niedernhofer LJ, et al. Ageing Res Rev. 2017 May;35:241-249. doi: 10.1016/j.arr.2016.09.012. Epub 2016 Oct 6. Ageing Res Rev. 2017. PMID: 27721062 Free PMC article. Review.
A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.
Ladiges W, Snyder JM, Wilkinson E, Imai DM, Snider T, Ge X, Ciol M, Pettan-Brewer C, Pillai SPS, Morton J, Quarles E, Rabinovitch P, Niedernhofer L, Liggitt D. Ladiges W, et al. J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):760-762. doi: 10.1093/gerona/glx019. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329081 Free PMC article.
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.
Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ. Yousefzadeh MJ, et al. Among authors: niedernhofer lj. Aging Cell. 2018 Apr;17(2):e12706. doi: 10.1111/acel.12706. Epub 2017 Dec 31. Aging Cell. 2018. PMID: 29290100 Free PMC article.
Fisetin is a senotherapeutic that extends health and lifespan.
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Among authors: niedernhofer lj. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. EBioMedicine. 2018. PMID: 30279143 Free PMC article.
Measuring biological age in mice using differential mass spectrometry.
Bell-Temin H, Yousefzadeh MJ, Bondarenko A, Quarles E, Jones-Laughner J, Robbins PD, Ladiges W, Niedernhofer LJ, Yates NA. Bell-Temin H, et al. Among authors: niedernhofer lj. Aging (Albany NY). 2019 Feb 11;11(3):1045-1061. doi: 10.18632/aging.101810. Aging (Albany NY). 2019. PMID: 30745468 Free PMC article.
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. Zhao J, et al. Among authors: niedernhofer lj. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. Aging (Albany NY). 2020. PMID: 32201398 Free PMC article.
Genetics of extreme human longevity to guide drug discovery for healthy ageing.
Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J. Zhang ZD, et al. Among authors: niedernhofer lj. Nat Metab. 2020 Aug;2(8):663-672. doi: 10.1038/s42255-020-0247-0. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719537 Free PMC article. Review.
184 results