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SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers.
Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, Shivange N, Wang DB, Post LA, Ferris HA, Hu S, Periasamy A, Bloom GS. Norambuena A, et al. Neurobiol Dis. 2022 Jul;169:105737. doi: 10.1016/j.nbd.2022.105737. Epub 2022 Apr 20. Neurobiol Dis. 2022. PMID: 35452786 Free PMC article.
We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-organelle signaling pathway where nutrient-stimulated lysosomal mTORC1 activity regulates mtDNA replication in neurons by a mechanism sensitive to amyloid-beta oligomers (AbetaOs), a p …
We previously discovered Nutrient-induced Mitochondrial Activity (NiMA), an inter-organelle signaling pathway where nutrient-stimulated lyso …
Dysregulation of mTOR by tau in Alzheimer's disease.
Bloom GS, Norambuena A. Bloom GS, et al. Among authors: norambuena a. Cytoskeleton (Hoboken). 2024 Jan;81(1):30-34. doi: 10.1002/cm.21782. Epub 2023 Aug 28. Cytoskeleton (Hoboken). 2024. PMID: 37638691 Free PMC article. Review.
Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers.
Sun X, Eastman G, Shi Y, Saibaba S, Oliveira AK, Lukens JR, Norambuena A, Thompson JA, Purdy MD, Dryden K, Pardo E, Mandell JW, Bloom GS. Sun X, et al. Among authors: norambuena a. Alzheimers Dement. 2024 Mar;20(3):1656-1670. doi: 10.1002/alz.13535. Epub 2023 Dec 9. Alzheimers Dement. 2024. PMID: 38069673 Free PMC article.
38 results