Young-Pearse TL - Search Results

1

Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis.

Sullivan SE, Liao M, Smith RV, White C, Lagomarsino VN, Xu J, Taga M, Bennett DA, De Jager PL, Young-Pearse TL. Sullivan SE, et al. Hum Mol Genet. 2019 Mar 1;28(5):718-735. doi: 10.1093/hmg/ddy376. Hum Mol Genet. 2019. PMID: 30371777 Free PMC article.

2

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.

Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. Muratore CR, et al. Hum Mol Genet. 2014 Jul 1;23(13):3523-36. doi: 10.1093/hmg/ddu064. Epub 2014 Feb 12. Hum Mol Genet. 2014. PMID: 24524897 Free PMC article.

3

Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease.

Sullivan SE, Young-Pearse TL. Sullivan SE, et al. Brain Res. 2017 Feb 1;1656:98-106. doi: 10.1016/j.brainres.2015.10.005. Epub 2015 Oct 13. Brain Res. 2017. PMID: 26459988 Free PMC article. Review.

4

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes.

Liao MC, Muratore CR, Gierahn TM, Sullivan SE, Srikanth P, De Jager PL, Love JC, Young-Pearse TL. Liao MC, et al. J Neurosci. 2016 Feb 3;36(5):1730-46. doi: 10.1523/JNEUROSCI.2735-15.2016. J Neurosci. 2016. PMID: 26843653 Free PMC article.

5

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL. Muratore CR, et al. Stem Cell Reports. 2017 Dec 12;9(6):1868-1884. doi: 10.1016/j.stemcr.2017.10.015. Epub 2017 Nov 16. Stem Cell Reports. 2017. PMID: 29153990 Free PMC article.

6

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids.

Srikanth P, Lagomarsino VN, Muratore CR, Ryu SC, He A, Taylor WM, Zhou C, Arellano M, Young-Pearse TL. Srikanth P, et al. Transl Psychiatry. 2018 Apr 12;8(1):77. doi: 10.1038/s41398-018-0122-x. Transl Psychiatry. 2018. PMID: 29643329 Free PMC article.

7

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.

Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, Yu L, Chibnik LB, Schneider JA, Young-Pearse TL, Bennett DA, De Jager PL. Mostafavi S, et al. Nat Neurosci. 2018 Jun;21(6):811-819. doi: 10.1038/s41593-018-0154-9. Epub 2018 May 25. Nat Neurosci. 2018. PMID: 29802388 Free PMC article.

8

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.

Yu L, Petyuk VA, Gaiteri C, Mostafavi S, Young-Pearse T, Shah RC, Buchman AS, Schneider JA, Piehowski PD, Sontag RL, Fillmore TL, Shi T, Smith RD, De Jager PL, Bennett DA. Yu L, et al. Ann Neurol. 2018 Jul;84(1):78-88. doi: 10.1002/ana.25266. Epub 2018 Jul 3. Ann Neurol. 2018. PMID: 29908079 Free PMC article.

9

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. Jin M, et al. Nat Commun. 2018 Jul 11;9(1):2676. doi: 10.1038/s41467-018-05068-w. Nat Commun. 2018. PMID: 29992960 Free PMC article.

10

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.

Raj T, Li YI, Wong G, Humphrey J, Wang M, Ramdhani S, Wang YC, Ng B, Gupta I, Haroutunian V, Schadt EE, Young-Pearse T, Mostafavi S, Zhang B, Sklar P, Bennett DA, De Jager PL. Raj T, et al. Nat Genet. 2018 Nov;50(11):1584-1592. doi: 10.1038/s41588-018-0238-1. Epub 2018 Oct 8. Nat Genet. 2018. PMID: 30297968 Free PMC article.

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