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Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
Zakharenko AL, Luzina OA, Sokolov DN, Kaledin VI, Nikolin VP, Popova NA, Patel J, Zakharova OD, Chepanova AA, Zafar A, Reynisson J, Leung E, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Zakharenko AL, et al. Among authors: zafar a. Eur J Med Chem. 2019 Jan 1;161:581-593. doi: 10.1016/j.ejmech.2018.10.055. Epub 2018 Oct 28. Eur J Med Chem. 2019. PMID: 30396105
Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.
Zakharova O, Luzina O, Zakharenko A, Sokolov D, Filimonov A, Dyrkheeva N, Chepanova A, Ilina E, Ilyina A, Klabenkova K, Chelobanov B, Stetsenko D, Zafar A, Eurtivong C, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O. Zakharova O, et al. Among authors: zafar a. Bioorg Med Chem. 2018 Aug 15;26(15):4470-4480. doi: 10.1016/j.bmc.2018.07.039. Epub 2018 Jul 24. Bioorg Med Chem. 2018. PMID: 30076000
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.
Ohui K, Afanasenko E, Bacher F, Ting RLX, Zafar A, Blanco-Cabra N, Torrents E, Dömötör O, May NV, Darvasiova D, Enyedy ÉA, Popović-Bijelić A, Reynisson J, Rapta P, Babak MV, Pastorin G, Arion VB. Ohui K, et al. Among authors: zafar a. J Med Chem. 2019 Jan 24;62(2):512-530. doi: 10.1021/acs.jmedchem.8b01031. Epub 2018 Dec 18. J Med Chem. 2019. PMID: 30507173 Free PMC article.
Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.
Leung E, Patel J, Hollywood JA, Zafar A, Tomek P, Barker D, Pilkington LI, van Rensburg M, Langley RJ, Helsby NA, Squire CJ, Baguley BC, Denny WA, Reynisson J, Leung IKH. Leung E, et al. Among authors: zafar a. Oncol Ther. 2021 Dec;9(2):541-556. doi: 10.1007/s40487-021-00158-0. Epub 2021 Jun 23. Oncol Ther. 2021. PMID: 34159519 Free PMC article.
The cytotoxic potential of cationic triangulenes against tumour cells.
Leung E, Pilkington LI, Naiya MM, Barker D, Zafar A, Eurtivong C, Reynisson J. Leung E, et al. Among authors: zafar a. Medchemcomm. 2019 Aug 21;10(11):1881-1891. doi: 10.1039/c9md00305c. eCollection 2019 Nov 1. Medchemcomm. 2019. PMID: 32952994 Free PMC article.
1,073 results