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Page 1
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.
Tobinaga H, Kameyama T, Asahi K, Horiguchi T, Oohara M, Taoda Y, Hata K, Hasegawa T, Tada Y, Kurihara N, Kanda Y, Yagi S, Tomari M, Tanaka Y, Takahashi F, Taniguchi E, Takahara Y, Shimada S, Takeyama C, Yamamoto S, Shinohara S, Kai H. Tobinaga H, et al. Among authors: hasegawa t. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127636. doi: 10.1016/j.bmcl.2020.127636. Epub 2020 Oct 22. Bioorg Med Chem Lett. 2020. PMID: 33132115
Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies.
Kai H, Horiguchi T, Kameyama T, Asahi K, Endoh T, Jikihara S, Hasegawa T, Tanaka S, Nozu A, Takeyama C, Tomari M, Takahashi F, Tamura N, Yagi S, Itoh T, Isou Y. Kai H, et al. Among authors: hasegawa t. Bioorg Med Chem Lett. 2021 Apr 1;37:127833. doi: 10.1016/j.bmcl.2021.127833. Epub 2021 Feb 2. Bioorg Med Chem Lett. 2021. PMID: 33540044
Structure-activity relationship studies and discovery of a potent transient receptor potential vanilloid (TRPV1) antagonist 4-[3-chloro-5-[(1S)-1,2-dihydroxyethyl]-2-pyridyl]-N-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2H-pyridine-1-carboxamide (V116517) as a clinical candidate for pain management.
Tafesse L, Kanemasa T, Kurose N, Yu J, Asaki T, Wu G, Iwamoto Y, Yamaguchi Y, Ni C, Engel J, Tsuno N, Patel A, Zhou X, Shintani T, Brown K, Hasegawa T, Shet M, Iso Y, Kato A, Kyle DJ. Tafesse L, et al. Among authors: hasegawa t. J Med Chem. 2014 Aug 14;57(15):6781-94. doi: 10.1021/jm500818a. Epub 2014 Aug 1. J Med Chem. 2014. PMID: 25057800
Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.
Nakahara K, Fuchino K, Komano K, Asada N, Tadano G, Hasegawa T, Yamamoto T, Sako Y, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI. Nakahara K, et al. Among authors: hasegawa t. J Med Chem. 2018 Jul 12;61(13):5525-5546. doi: 10.1021/acs.jmedchem.8b00011. Epub 2018 Jun 14. J Med Chem. 2018. PMID: 29775538
Efficacy and safety of remote cardiac rehabilitation in the recovery phase of cardiovascular diseases (RecRCR study): A multicenter, nonrandomized, and interventional trial in Japan.
Itoh H, Amiya E, Jimba T, Shimbo M, Narita K, Taya M, Kadokami T, Yasu T, Oka H, Sogawa M, Yokoi H, Mizutani K, Miura SI, Tokeshi T, Date A, Noma T, Kutsuzawa D, Usui S, Sugawara S, Kanazawa M, Sekino H, Nishitani Yokoyama M, Okumura T, Ugata Y, Fujishima S, Hirabayashi K, Ishizaki Y, Kuwahara K, Kaji Y, Shimizu H, Koyama T, Adachi H, Kurumatani Y, Taniguchi R, Ohori K, Shiraishi H, Hasegawa T, Makita S, Komuro I, Kimura Y; RecRCR registry investigators. Itoh H, et al. Among authors: hasegawa t. Int J Cardiol Heart Vasc. 2024 May 17;52:101421. doi: 10.1016/j.ijcha.2024.101421. eCollection 2024 Jun. Int J Cardiol Heart Vasc. 2024. PMID: 38799401 Free PMC article.
Prediction of Mismatch Repair Status in Endometrial Cancer from Histological Slide Images Using Various Deep Learning-Based Algorithms.
Umemoto M, Mariya T, Nambu Y, Nagata M, Horimai T, Sugita S, Kanaseki T, Takenaka Y, Shinkai S, Matsuura M, Iwasaki M, Hirohashi Y, Hasegawa T, Torigoe T, Fujino Y, Saito T. Umemoto M, et al. Among authors: hasegawa t. Cancers (Basel). 2024 May 9;16(10):1810. doi: 10.3390/cancers16101810. Cancers (Basel). 2024. PMID: 38791889 Free PMC article.
One-year outcomes and safety assessment of faricimab in treatment-naïve patients with neovascular age-related macular degeneration in Japan.
Mukai R, Kataoka K, Tanaka K, Miyara Y, Maruko I, Nakayama M, Watanabe Y, Yamamoto A, Wakatsuki Y, Onoe H, Wakugawa S, Terao N, Hasegawa T, Kawai M, Maruko R, Itagaki K, Honjo J, Okada AA, Mori R, Koizumi H, Iida T, Sekiryu T. Mukai R, et al. Among authors: hasegawa t. Sci Rep. 2024 May 22;14(1):11681. doi: 10.1038/s41598-024-62559-1. Sci Rep. 2024. PMID: 38778065 Free PMC article.
6,326 results