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Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
Morgan RG, Walker AE, Trott DW, Machin DR, Henson GD, Reihl KD, Cawthon RM, Denchi EL, Liu Y, Bloom SI, Phuong TT, Richardson RS, Lesniewski LA, Donato AJ. Morgan RG, et al. Among authors: cawthon rm. J Mol Cell Cardiol. 2019 Feb;127:74-82. doi: 10.1016/j.yjmcc.2018.11.014. Epub 2018 Nov 29. J Mol Cell Cardiol. 2019. PMID: 30502348 Free PMC article.
Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries.
Morgan RG, Ives SJ, Lesniewski LA, Cawthon RM, Andtbacka RH, Noyes RD, Richardson RS, Donato AJ. Morgan RG, et al. Among authors: cawthon rm. Am J Physiol Heart Circ Physiol. 2013 Jul 15;305(2):H251-8. doi: 10.1152/ajpheart.00197.2013. Epub 2013 May 10. Am J Physiol Heart Circ Physiol. 2013. PMID: 23666675 Free PMC article.
Accelerated telomere shortening in response to life stress.
Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. Epel ES, et al. Among authors: cawthon rm. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5. doi: 10.1073/pnas.0407162101. Epub 2004 Dec 1. Proc Natl Acad Sci U S A. 2004. PMID: 15574496 Free PMC article.
Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study.
Carlquist JF, Knight S, Cawthon RM, Le VT, Jared Bunch T, Horne BD, Rollo JS, Huntinghouse JA, Brent Muhlestein J, Anderson JL. Carlquist JF, et al. Among authors: cawthon rm. Heart Rhythm. 2016 Jan;13(1):21-7. doi: 10.1016/j.hrthm.2015.07.032. Epub 2015 Jul 29. Heart Rhythm. 2016. PMID: 26231419
107 results