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Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.
Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J. Mariappan A, et al. Among authors: schmalz hg. EMBO J. 2019 Jan 15;38(2):e99876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10. EMBO J. 2019. PMID: 30530478 Free PMC article.
B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner.
Stein A, Hilken Née Thomopoulou P, Frias C, Hopff SM, Varela P, Wilke N, Mariappan A, Neudörfl JM, Fedorov AY, Gopalakrishnan J, Gigant B, Prokop A, Schmalz HG. Stein A, et al. Among authors: schmalz hg. ACS Omega. 2022 Jan 11;7(3):2591-2603. doi: 10.1021/acsomega.1c04659. eCollection 2022 Jan 25. ACS Omega. 2022. PMID: 35097257 Free PMC article.
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Barone M, et al. Among authors: schmalz hg. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184177 Free PMC article.
Phenanthroindolizidine Alkaloids Isolated from Tylophora ovata as Potent Inhibitors of Inflammation, Spheroid Growth, and Invasion of Triple-Negative Breast Cancer.
Reimche I, Yu H, Ariantari NP, Liu Z, Merkens K, Rotfuß S, Peter K, Jungwirth U, Bauer N, Kiefer F, Neudörfl JM, Schmalz HG, Proksch P, Teusch N. Reimche I, et al. Among authors: schmalz hg. Int J Mol Sci. 2022 Sep 7;23(18):10319. doi: 10.3390/ijms231810319. Int J Mol Sci. 2022. PMID: 36142230 Free PMC article.
115 results