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The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain.
Brown AD, Bagal SK, Blackwell P, Blakemore DC, Brown B, Bungay PJ, Corless M, Crawforth J, Fengas D, Fenwick DR, Gray V, Kemp M, Klute W, Malet Sanz L, Miller D, Murata Y, Payne CE, Skerratt S, Stevens EB, Warmus JS. Brown AD, et al. Among authors: brown b. Bioorg Med Chem. 2019 Jan 1;27(1):230-239. doi: 10.1016/j.bmc.2018.12.002. Epub 2018 Dec 4. Bioorg Med Chem. 2019. PMID: 30538065
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
Swain NA, Batchelor D, Beaudoin S, Bechle BM, Bradley PA, Brown AD, Brown B, Butcher KJ, Butt RP, Chapman ML, Denton S, Ellis D, Galan SRG, Gaulier SM, Greener BS, de Groot MJ, Glossop MS, Gurrell IK, Hannam J, Johnson MS, Lin Z, Markworth CJ, Marron BE, Millan DS, Nakagawa S, Pike A, Printzenhoff D, Rawson DJ, Ransley SJ, Reister SM, Sasaki K, Storer RI, Stupple PA, West CW. Swain NA, et al. Among authors: brown b, brown ad. J Med Chem. 2017 Aug 24;60(16):7029-7042. doi: 10.1021/acs.jmedchem.7b00598. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28682065
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits.
Wietek J, Nozownik A, Pulin M, Saraf-Sinik I, Matosevich N, Gowrishankar R, Gat A, Malan D, Brown BJ, Dine J, Imambocus BN, Levy R, Sauter K, Litvin A, Regev N, Subramaniam S, Abrera K, Summarli D, Goren EM, Mizrachi G, Bitton E, Benjamin A, Copits BA, Sasse P, Rost BR, Schmitz D, Bruchas MR, Soba P, Oren-Suissa M, Nir Y, Wiegert JS, Yizhar O. Wietek J, et al. Among authors: brown bj. Nat Methods. 2024 May 29. doi: 10.1038/s41592-024-02285-8. Online ahead of print. Nat Methods. 2024. PMID: 38811857
The genome of Przewalski's horse (Equus ferus przewalskii).
Flack N, Hughes L, Cassens J, Enriquez M, Gebeyehu S, Alshagawi M, Hatfield J, Kauffman A, Brown B, Klaeui C, Mabrouk IF, Walls C, Yeater T, Rivas A, Faulk C. Flack N, et al. Among authors: brown b. G3 (Bethesda). 2024 May 28:jkae113. doi: 10.1093/g3journal/jkae113. Online ahead of print. G3 (Bethesda). 2024. PMID: 38805182
The solar dynamo begins near the surface.
Vasil GM, Lecoanet D, Augustson K, Burns KJ, Oishi JS, Brown BP, Brummell N, Julien K. Vasil GM, et al. Among authors: brown bp. Nature. 2024 May;629(8013):769-772. doi: 10.1038/s41586-024-07315-1. Epub 2024 May 22. Nature. 2024. PMID: 38778233 Free PMC article.
Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation.
Wang S, Zhang Y, Zhong Y, Xue Y, Liu Z, Wang C, Kang DD, Li H, Hou X, Tian M, Cao D, Wang L, Guo K, Deng B, McComb DW, Merad M, Brown BD, Dong Y. Wang S, et al. Among authors: brown bd. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2322935121. doi: 10.1073/pnas.2322935121. Epub 2024 May 21. Proc Natl Acad Sci U S A. 2024. PMID: 38771877
Associations Between Neighborhood Resources and Youths' Response to Reward Omission in a Task Modeling Negatively Biased Environments.
Brown B, Nguyen LT, Morales I, Cardinale EM, Tseng WL, McKay CC, Kircanski K, Brotman MA, Pine DS, Leibenluft E, Linke JO. Brown B, et al. J Am Acad Child Adolesc Psychiatry. 2024 May 17:S0890-8567(24)00253-3. doi: 10.1016/j.jaac.2024.05.011. Online ahead of print. J Am Acad Child Adolesc Psychiatry. 2024. PMID: 38763411 Free article.
5,169 results