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Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A. Michalska K, et al. Among authors: chuang e. Structure. 2019 Mar 5;27(3):449-463.e7. doi: 10.1016/j.str.2018.11.001. Epub 2018 Dec 27. Structure. 2019. PMID: 30595457 Free PMC article.
Mechanistic Insights into Hsp104 Potentiation.
Torrente MP, Chuang E, Noll MM, Jackrel ME, Go MS, Shorter J. Torrente MP, et al. Among authors: chuang e. J Biol Chem. 2016 Mar 4;291(10):5101-15. doi: 10.1074/jbc.M115.707976. Epub 2016 Jan 8. J Biol Chem. 2016. PMID: 26747608 Free PMC article.
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.
Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Gates SN, et al. Among authors: chuang e. Science. 2017 Jul 21;357(6348):273-279. doi: 10.1126/science.aan1052. Epub 2017 Jun 15. Science. 2017. PMID: 28619716 Free PMC article.
Amyloid assembly and disassembly.
Chuang E, Hori AM, Hesketh CD, Shorter J. Chuang E, et al. J Cell Sci. 2018 Apr 13;131(8):jcs189928. doi: 10.1242/jcs.189928. J Cell Sci. 2018. PMID: 29654159 Free PMC article. Review.
Therapeutic genetic variation revealed in diverse Hsp104 homologs.
March ZM, Sweeney K, Kim H, Yan X, Castellano LM, Jackrel ME, Lin J, Chuang E, Gomes E, Willicott CW, Michalska K, Jedrzejczak RP, Joachimiak A, Caldwell KA, Caldwell GA, Shalem O, Shorter J. March ZM, et al. Among authors: chuang e. Elife. 2020 Dec 15;9:e57457. doi: 10.7554/eLife.57457. Elife. 2020. PMID: 33319748 Free PMC article.
Tuning Hsp104 specificity to selectively detoxify α-synuclein.
Mack KL, Kim H, Barbieri EM, Lin J, Braganza S, Jackrel ME, DeNizio JE, Yan X, Chuang E, Tariq A, Cupo RR, Castellano LM, Caldwell KA, Caldwell GA, Shorter J. Mack KL, et al. Among authors: chuang e. Mol Cell. 2023 Sep 21;83(18):3314-3332.e9. doi: 10.1016/j.molcel.2023.07.029. Epub 2023 Aug 24. Mol Cell. 2023. PMID: 37625404
Design principles to tailor Hsp104 therapeutics.
Lin J, Carman PJ, Gambogi CW, Kendsersky NM, Chuang E, Gates SN, Yokom AL, Rizo AN, Southworth DR, Shorter J. Lin J, et al. Among authors: chuang e. bioRxiv [Preprint]. 2024 Apr 28:2024.04.26.591398. doi: 10.1101/2024.04.26.591398. bioRxiv. 2024. PMID: 38712168 Free PMC article. Preprint.
509 results