Segal DJ - Search Results

1

Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design.

De Franco S, Vandenameele J, Brans A, Verlaine O, Bendak K, Damblon C, Matagne A, Segal DJ, Galleni M, Mackay JP, Vandevenne M. De Franco S, et al. Among authors: segal dj. Sci Rep. 2019 Feb 21;9(1):2484. doi: 10.1038/s41598-019-38655-y. Sci Rep. 2019. PMID: 30792407 Free PMC article.

2

Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker.

Shimizu Y, Bhakta MS, Segal DJ. Shimizu Y, et al. Among authors: segal dj. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3970-2. doi: 10.1016/j.bmcl.2009.02.109. Epub 2009 Mar 3. Bioorg Med Chem Lett. 2009. PMID: 19289279 Free PMC article.

3

The generation of zinc finger proteins by modular assembly.

Bhakta MS, Segal DJ. Bhakta MS, et al. Among authors: segal dj. Methods Mol Biol. 2010;649:3-30. doi: 10.1007/978-1-60761-753-2_1. Methods Mol Biol. 2010. PMID: 20680825 Free PMC article.

4

A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications.

Kim MS, Stybayeva G, Lee JY, Revzin A, Segal DJ. Kim MS, et al. Among authors: segal dj. Nucleic Acids Res. 2011 Mar;39(5):e29. doi: 10.1093/nar/gkq1214. Epub 2010 Dec 5. Nucleic Acids Res. 2011. PMID: 21134909 Free PMC article.

5

The prospects for designer single-stranded RNA-binding proteins.

Mackay JP, Font J, Segal DJ. Mackay JP, et al. Among authors: segal dj. Nat Struct Mol Biol. 2011 Mar;18(3):256-61. doi: 10.1038/nsmb.2005. Epub 2011 Feb 27. Nat Struct Mol Biol. 2011. PMID: 21358629

6

Adding fingers to an engineered zinc finger nuclease can reduce activity.

Shimizu Y, Şöllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ. Shimizu Y, et al. Among authors: segal dj. Biochemistry. 2011 Jun 7;50(22):5033-41. doi: 10.1021/bi200393g. Epub 2011 May 11. Biochemistry. 2011. PMID: 21528840 Free PMC article.

7

Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA.

O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP. O'Connell MR, et al. Among authors: segal dj. Angew Chem Int Ed Engl. 2012 May 29;51(22):5371-5. doi: 10.1002/anie.201200866. Epub 2012 Apr 19. Angew Chem Int Ed Engl. 2012. PMID: 22517726 Free article. No abstract available.

8

New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217.

Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP. Vandevenne M, et al. Among authors: segal dj. J Biol Chem. 2013 Apr 12;288(15):10616-27. doi: 10.1074/jbc.M112.441451. Epub 2013 Feb 22. J Biol Chem. 2013. PMID: 23436653 Free PMC article.

9

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

Mackay JP, Segal DJ, Crossley M. Mackay JP, et al. Among authors: segal dj. Trends Biochem Sci. 2013 Sep;38(9):421-2. doi: 10.1016/j.tibs.2013.06.005. Trends Biochem Sci. 2013. PMID: 23992945 No abstract available.

10

Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.

Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP. Vandevenne M, et al. Among authors: segal dj. Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7848-52. doi: 10.1002/anie.201402980. Epub 2014 Jul 9. Angew Chem Int Ed Engl. 2014. PMID: 25044781 Free article.

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