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Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.
Densham RM, Garvin AJ, Stone HR, Strachan J, Baldock RA, Daza-Martin M, Fletcher A, Blair-Reid S, Beesley J, Johal B, Pearl LH, Neely R, Keep NH, Watts FZ, Morris JR. Densham RM, et al. Among authors: stone hr. Nat Struct Mol Biol. 2016 Jul;23(7):647-55. doi: 10.1038/nsmb.3236. Epub 2016 May 30. Nat Struct Mol Biol. 2016. PMID: 27239795 Free PMC article.
Isomerization of BRCA1-BARD1 promotes replication fork protection.
Daza-Martin M, Starowicz K, Jamshad M, Tye S, Ronson GE, MacKay HL, Chauhan AS, Walker AK, Stone HR, Beesley JFJ, Coles JL, Garvin AJ, Stewart GS, McCorvie TJ, Zhang X, Densham RM, Morris JR. Daza-Martin M, et al. Among authors: stone hr. Nature. 2019 Jul;571(7766):521-527. doi: 10.1038/s41586-019-1363-4. Epub 2019 Jul 3. Nature. 2019. PMID: 31270457
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.
Mackay HL, Stone HR, Ellis K, Ronson GE, Walker AK, Starowicz K, Garvin AJ, van Eijk P, Vaitsiankova A, Vijayendran S, Beesley JF, Petermann E, Brown EJ, Densham RM, Reed SH, Dobbs F, Saponaro M, Morris JR. Mackay HL, et al. Among authors: stone hr. bioRxiv [Preprint]. 2024 Jan 11:2024.01.10.574674. doi: 10.1101/2024.01.10.574674. bioRxiv. 2024. PMID: 38260523 Free PMC article. Preprint.