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Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C. Scharfenberg F, et al. Among authors: lichtenthaler sf. Cell Mol Life Sci. 2020 Jan;77(2):331-350. doi: 10.1007/s00018-019-03184-4. Epub 2019 Jun 17. Cell Mol Life Sci. 2020. PMID: 31209506 Free PMC article.
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW. Moss ML, et al. Among authors: lichtenthaler sf. J Biol Chem. 2011 Nov 25;286(47):40443-51. doi: 10.1074/jbc.M111.280495. Epub 2011 Sep 28. J Biol Chem. 2011. PMID: 21956108 Free PMC article.
The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity.
Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kümpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, Meinl E. Hoffmann FS, et al. Among authors: lichtenthaler sf. J Immunol. 2015 Jan 15;194(2):542-52. doi: 10.4049/jimmunol.1402070. Epub 2014 Dec 10. J Immunol. 2015. PMID: 25505277 Free PMC article. Clinical Trial.
187 results