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Discovery of NV-5138, the first selective Brain mTORC1 activator.
Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, O'Neill D, Vlasuk GP, Saiah E. Sengupta S, et al. Among authors: hahm s. Sci Rep. 2019 Mar 11;9(1):4107. doi: 10.1038/s41598-019-40693-5. Sci Rep. 2019. PMID: 30858438 Free PMC article.
Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
Xiang J, Wan ZK, Li HQ, Ipek M, Binnun E, Nunez J, Chen L, McKew JC, Mansour TS, Xu X, Suri V, Tam M, Xing Y, Li X, Hahm S, Tobin J, Saiah E. Xiang J, et al. Among authors: hahm s. J Med Chem. 2008 Jul 24;51(14):4068-71. doi: 10.1021/jm8004948. Epub 2008 Jun 26. J Med Chem. 2008. PMID: 18578516
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.
Wan ZK, Chenail E, Li HQ, Ipek M, Xiang J, Suri V, Hahm S, Bard J, Svenson K, Xu X, Tian X, Wang M, Li X, Johnson CE, Qadri A, Panza D, Perreault M, Mansour TS, Tobin JF, Saiah E. Wan ZK, et al. Among authors: hahm s. ACS Med Chem Lett. 2012 Nov 23;4(1):118-23. doi: 10.1021/ml300352x. eCollection 2013 Jan 10. ACS Med Chem Lett. 2012. PMID: 24900572 Free PMC article.
Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.
Cao J, Zhou Y, Peng H, Huang X, Stahler S, Suri V, Qadri A, Gareski T, Jones J, Hahm S, Perreault M, McKew J, Shi M, Xu X, Tobin JF, Gimeno RE. Cao J, et al. Among authors: hahm s. J Biol Chem. 2011 Dec 2;286(48):41838-41851. doi: 10.1074/jbc.M111.245456. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990351 Free PMC article.
137 results