Saiah E - Search Results

1

Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters.

Kang SA, O'Neill DJ, Machl AW, Lumpkin CJ, Galda SN, Sengupta S, Mahoney SJ, Howell JJ, Molz L, Hahm S, Vlasuk GP, Saiah E. Kang SA, et al. Among authors: saiah e. Cell Chem Biol. 2019 Sep 19;26(9):1203-1213.e13. doi: 10.1016/j.chembiol.2019.05.009. Epub 2019 Jun 20. Cell Chem Biol. 2019. PMID: 31231029 Free article.

2

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.

Mahoney SJ, Narayan S, Molz L, Berstler LA, Kang SA, Vlasuk GP, Saiah E. Mahoney SJ, et al. Among authors: saiah e. Nat Commun. 2018 Feb 7;9(1):548. doi: 10.1038/s41467-018-03035-z. Nat Commun. 2018. PMID: 29416044 Free PMC article.

3

Discovery of NV-5138, the first selective Brain mTORC1 activator.

Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, O'Neill D, Vlasuk GP, Saiah E. Sengupta S, et al. Among authors: saiah e. Sci Rep. 2019 Mar 11;9(1):4107. doi: 10.1038/s41598-019-40693-5. Sci Rep. 2019. PMID: 30858438 Free PMC article.

4

Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation.

Kato T, Pothula S, Liu RJ, Duman CH, Terwilliger R, Vlasuk GP, Saiah E, Hahm S, Duman RS. Kato T, et al. Among authors: saiah e. J Clin Invest. 2019 Apr 16;129(6):2542-2554. doi: 10.1172/JCI126859. J Clin Invest. 2019. PMID: 30990795 Free PMC article.

5

Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy.

St-Cyr S, Child DD, Giaime E, Smith AR, Pascua CJ, Hahm S, Saiah E, Davidson BL. St-Cyr S, et al. Among authors: saiah e. PLoS One. 2022 Aug 29;17(8):e0273710. doi: 10.1371/journal.pone.0273710. eCollection 2022. PLoS One. 2022. PMID: 36037192 Free PMC article.

6

Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.

Xiang J, Wan ZK, Li HQ, Ipek M, Binnun E, Nunez J, Chen L, McKew JC, Mansour TS, Xu X, Suri V, Tam M, Xing Y, Li X, Hahm S, Tobin J, Saiah E. Xiang J, et al. Among authors: saiah e. J Med Chem. 2008 Jul 24;51(14):4068-71. doi: 10.1021/jm8004948. Epub 2008 Jun 26. J Med Chem. 2008. PMID: 18578516

7

Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.

Wan ZK, Chenail E, Xiang J, Li HQ, Ipek M, Bard J, Svenson K, Mansour TS, Xu X, Tian X, Suri V, Hahm S, Xing Y, Johnson CE, Li X, Qadri A, Panza D, Perreault M, Tobin JF, Saiah E. Wan ZK, et al. Among authors: saiah e. J Med Chem. 2009 Sep 10;52(17):5449-61. doi: 10.1021/jm900639u. J Med Chem. 2009. PMID: 19673466

8

Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.

Wan ZK, Chenail E, Li HQ, Ipek M, Xiang J, Suri V, Hahm S, Bard J, Svenson K, Xu X, Tian X, Wang M, Li X, Johnson CE, Qadri A, Panza D, Perreault M, Mansour TS, Tobin JF, Saiah E. Wan ZK, et al. Among authors: saiah e. ACS Med Chem Lett. 2012 Nov 23;4(1):118-23. doi: 10.1021/ml300352x. eCollection 2013 Jan 10. ACS Med Chem Lett. 2012. PMID: 24900572 Free PMC article.

9

Comparative pharmacokinetics and metabolism studies in lean and diet- induced obese mice: an animal efficacy model for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.

Wang M, Tian X, Leung L, Wang J, Houvig N, Xiang J, Wan ZK, Saiah E, Hahm S, Suri V, Xu X. Wang M, et al. Among authors: saiah e. Drug Metab Lett. 2011 Jan;5(1):55-63. doi: 10.2174/187231211794455280. Drug Metab Lett. 2011. PMID: 21198436

10

Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice.

Perreault M, Will S, Panza D, Gareski T, Harding K, Kubasiak D, Jalenak M, Gartrell K, Wang S, Bollag G, Artis DR, Ibrahim PN, Womack P, Lin JJ, Saiah E, Mansour TS, Vlasuk GP, Erbe DV, Tobin JF. Perreault M, et al. Among authors: saiah e. Diabetes Obes Metab. 2010 Mar;12(3):234-45. doi: 10.1111/j.1463-1326.2009.01157.x. Diabetes Obes Metab. 2010. PMID: 20152000

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