Schnetz-Boutaud NC - Search Results

1

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M₄ PAMs.

Chopko TC, Han C, Gregro AR, Engers DW, Felts AS, Poslusney MS, Bollinger KA, Morrison RD, Bubser M, Lamsal A, Luscombe VB, Cho HP, Schnetz-Boutaud NC, Rodriguez AL, Chang S, Daniels JS, Stec DF, Niswender CM, Jones CK, Wood MR, Wood MW, Duggan ME, Brandon NJ, Conn PJ, Bridges TM, Lindsley CW, Melancon BJ. Chopko TC, et al. Among authors: schnetz boutaud nc. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2224-2228. doi: 10.1016/j.bmcl.2019.06.032. Epub 2019 Jun 20. Bioorg Med Chem Lett. 2019. PMID: 31248774 Free PMC article.

2

Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M₅ Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.

Garrison AT, Orsi DL, Capstick RA, Whomble D, Li J, Carter TR, Felts AS, Vinson PN, Rodriguez AL, Han A, Hajari K, Cho HP, Teal LB, Ragland MG, Ghamari-Langroudi M, Bubser M, Chang S, Schnetz-Boutaud NC, Boutaud O, Blobaum AL, Foster DJ, Niswender CM, Conn PJ, Lindsley CW, Jones CK, Han C. Garrison AT, et al. Among authors: schnetz boutaud nc. J Med Chem. 2022 Apr 28;65(8):6273-6286. doi: 10.1021/acs.jmedchem.2c00192. Epub 2022 Apr 13. J Med Chem. 2022. PMID: 35417155

3

Pyrimido[1,2-alpha]purin-10(3H)-one: a reactive electrophile in the genome.

Schnetz-Boutaud N, Daniels JS, Hashim MF, Scholl P, Burrus T, Marnett LJ. Schnetz-Boutaud N, et al. Chem Res Toxicol. 2000 Oct;13(10):967-70. doi: 10.1021/tx000135i. Chem Res Toxicol. 2000. PMID: 11080044

4

Bulge migration of the malondialdehyde OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.

Wang Y, Schnetz-Boutaud NC, Saleh S, Marnett LJ, Stone MP. Wang Y, et al. Among authors: schnetz boutaud nc. Chem Res Toxicol. 2007 Aug;20(8):1200-10. doi: 10.1021/tx700121j. Epub 2007 Jul 24. Chem Res Toxicol. 2007. PMID: 17645303 Free PMC article.

5

Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M(1)G.

Schnetz-Boutaud NC, Mao H, Stone MP, Marnett LJ. Schnetz-Boutaud NC, et al. Chem Res Toxicol. 2000 Feb;13(2):90-5. doi: 10.1021/tx990141i. Chem Res Toxicol. 2000. PMID: 10688532

6

Temperature-dependent formation of a conjugate between tris(hydroxymethyl)aminomethane buffer and the malondialdehyde-DNA adduct pyrimidopurinone.

Niedernhofer LJ, Riley M, Schnetz-Boutaud N, Sanduwaran G, Chaudhary AK, Reddy GR, Marnett LJ. Niedernhofer LJ, et al. Chem Res Toxicol. 1997 May;10(5):556-61. doi: 10.1021/tx960191c. Chem Res Toxicol. 1997. PMID: 9168253

7

In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcome.

Hashim MF, Riggins JN, Schnetz-Boutaud N, Voehler M, Stone MP, Marnett LJ. Hashim MF, et al. Biochemistry. 2004 Sep 21;43(37):11828-35. doi: 10.1021/bi049360f. Biochemistry. 2004. PMID: 15362868

8

Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct.

Mao H, Schnetz-Boutaud NC, Weisenseel JP, Marnett LJ, Stone MP. Mao H, et al. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6615-20. doi: 10.1073/pnas.96.12.6615. Proc Natl Acad Sci U S A. 1999. PMID: 10359760 Free PMC article.

9

The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.

Schnetz-Boutaud NC, Saleh S, Marnett LJ, Stone MP. Schnetz-Boutaud NC, et al. Biochemistry. 2001 Dec 25;40(51):15638-49. doi: 10.1021/bi011242u. Biochemistry. 2001. PMID: 11747439

10

Structure of the malondialdehyde deoxyguanosine adduct M1G when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene.

Schnetz-Boutaud NC, Saleh S, Marnett LJ, Stone MP. Schnetz-Boutaud NC, et al. Adv Exp Med Biol. 2001;500:513-6. doi: 10.1007/978-1-4615-0667-6_77. Adv Exp Med Biol. 2001. PMID: 11764989

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