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ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer.
Saad MI, Alhayyani S, McLeod L, Yu L, Alanazi M, Deswaerte V, Tang K, Jarde T, Smith JA, Prodanovic Z, Tate MD, Balic JJ, Watkins DN, Cain JE, Bozinovski S, Algar E, Kohmoto T, Ebi H, Ferlin W, Garbers C, Ruwanpura S, Sagi I, Rose-John S, Jenkins BJ. Saad MI, et al. Among authors: yu l. EMBO Mol Med. 2019 Apr;11(4):e9976. doi: 10.15252/emmm.201809976. EMBO Mol Med. 2019. PMID: 30833304 Free PMC article.
Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism.
Deswaerte V, Nguyen P, West A, Browning AF, Yu L, Ruwanpura SM, Balic J, Livis T, Girard C, Preaudet A, Oshima H, Fung KY, Tye H, Najdovska M, Ernst M, Oshima M, Gabay C, Putoczki T, Jenkins BJ. Deswaerte V, et al. Among authors: yu l. Cancer Res. 2018 Mar 1;78(5):1293-1307. doi: 10.1158/0008-5472.CAN-17-1887. Epub 2017 Dec 27. Cancer Res. 2018. PMID: 29282220
Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer.
Alhayyani S, McLeod L, West AC, Balic JJ, Hodges C, Yu L, Smith JA, Prodanovic Z, Bozinovski S, Kumar B, Ruwanpura SM, Saad MI, Jenkins BJ. Alhayyani S, et al. Among authors: yu l. Oncogene. 2022 Feb;41(6):809-823. doi: 10.1038/s41388-021-02134-4. Epub 2021 Dec 3. Oncogene. 2022. PMID: 34857889
Toll-like Receptor 9 Promotes Initiation of Gastric Tumorigenesis by Augmenting Inflammation and Cellular Proliferation.
Tang K, McLeod L, Livis T, West AC, Dawson R, Yu L, Balic JJ, Chonwerawong M, Wray-McCann G, Oshima H, Oshima M, Deswaerte V, Ferrero RL, Jenkins BJ. Tang K, et al. Among authors: yu l. Cell Mol Gastroenterol Hepatol. 2022;14(3):567-586. doi: 10.1016/j.jcmgh.2022.06.002. Epub 2022 Jun 15. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35716851 Free PMC article.
STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis.
Dawson RE, Deswaerte V, West AC, Tang K, West AJ, Balic JJ, Gearing LJ, Saad MI, Yu L, Wu Y, Bhathal PS, Kumar B, Chakrabarti JT, Zavros Y, Oshima H, Klinman DM, Oshima M, Tan P, Jenkins BJ. Dawson RE, et al. Among authors: yu l. Gut. 2022 Aug;71(8):1515-1531. doi: 10.1136/gutjnl-2020-323916. Epub 2021 Sep 6. Gut. 2022. PMID: 34489308
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