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Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.
Circ Res. 2019 Aug 30;125(6):575-589. doi: 10.1161/CIRCRESAHA.119.315313. Epub 2019 Aug 1.
Circ Res. 2019.
PMID: 31366290
Free PMC article.
Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function.
Vincentz JW, Toolan KP, Zhang W, Firulli AB.
Vincentz JW, et al. Among authors: toolan kp.
PLoS Genet. 2017 Jul 21;13(7):e1006922. doi: 10.1371/journal.pgen.1006922. eCollection 2017 Jul.
PLoS Genet. 2017.
PMID: 28732025
Free PMC article.
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The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice.
Firulli BA, Toolan KP, Harkin J, Millar H, Pineda S, Firulli AB.
Firulli BA, et al. Among authors: toolan kp.
Cardiovasc Res. 2017 Dec 1;113(14):1732-1742. doi: 10.1093/cvr/cvx166.
Cardiovasc Res. 2017.
PMID: 29016838
Free PMC article.
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HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.
Firulli BA, George RM, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W, Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M, Firulli AB.
Firulli BA, et al. Among authors: toolan kp.
Cardiovasc Res. 2020 Mar 1;116(3):605-618. doi: 10.1093/cvr/cvz182.
Cardiovasc Res. 2020.
PMID: 31286141
Free PMC article.
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HAND transcription factors cooperatively specify the aorta and pulmonary trunk.
Vincentz JW, Firulli BA, Toolan KP, Osterwalder M, Pennacchio LA, Firulli AB.
Vincentz JW, et al. Among authors: toolan kp.
Dev Biol. 2021 Aug;476:1-10. doi: 10.1016/j.ydbio.2021.03.011. Epub 2021 Mar 20.
Dev Biol. 2021.
PMID: 33757801
Free PMC article.
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Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.
Firulli BA, Milliar H, Toolan KP, Harkin J, Fuchs RK, Robling AG, Firulli AB.
Firulli BA, et al. Among authors: toolan kp.
Development. 2017 Jul 1;144(13):2480-2489. doi: 10.1242/dev.149963. Epub 2017 Jun 2.
Development. 2017.
PMID: 28576769
Free PMC article.
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Otx2b mutant zebrafish have pituitary, eye and mandible defects that model mammalian disease.
Bando H, Gergics P, Bohnsack BL, Toolan KP, Richter CE, Shavit JA, Camper SA.
Bando H, et al. Among authors: toolan kp.
Hum Mol Genet. 2020 Jun 27;29(10):1648-1657. doi: 10.1093/hmg/ddaa064.
Hum Mol Genet. 2020.
PMID: 32277752
Free PMC article.
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Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degeneration.
Wubben TJ, Pawar M, Smith A, Toolan K, Hager H, Besirli CG.
Wubben TJ, et al.
Sci Rep. 2017 Dec 19;7(1):17863. doi: 10.1038/s41598-017-18098-z.
Sci Rep. 2017.
PMID: 29259242
Free PMC article.
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