Lynn SM - Search Results

1

Profile of a Highly Selective Quaternized Pyrrolidine Betaine α_vβ₆ Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.

Barrett TN, Taylor JA, Barker D, Procopiou PA, Thompson JDF, Barrett J, Le J, Lynn SM, Pogany P, Pratley C, Pritchard JM, Roper JA, Rowedder JE, Slack RJ, Vitulli G, Macdonald SJF, Kerr WJ. Barrett TN, et al. Among authors: lynn sm. J Med Chem. 2019 Aug 22;62(16):7543-7556. doi: 10.1021/acs.jmedchem.9b00819. Epub 2019 Aug 5. J Med Chem. 2019. PMID: 31381331 Free article.

2

Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists.

Procopiou PA, Browning C, Gore PM, Lynn SM, Richards SA, Slack RJ, Sollis SL. Procopiou PA, et al. Among authors: lynn sm. Bioorg Med Chem. 2012 Oct 15;20(20):6097-108. doi: 10.1016/j.bmc.2012.08.032. Epub 2012 Aug 31. Bioorg Med Chem. 2012. PMID: 22985961

3

Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis.

Anderson NA, Campbell IB, Fallon BJ, Lynn SM, Macdonald SJ, Pritchard JM, Procopiou PA, Sollis SL, Thorp LR. Anderson NA, et al. Among authors: lynn sm. Org Biomol Chem. 2016 Jul 7;14(25):5992-6009. doi: 10.1039/c6ob00496b. Epub 2016 May 26. Org Biomol Chem. 2016. PMID: 27226381

4

2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis.

Shukla L, Ajram LA, Begg M, Evans B, Graves RH, Hodgson ST, Lynn SM, Miah AH, Percy JM, Procopiou PA, Richards SA, Slack RJ. Shukla L, et al. Among authors: lynn sm. Eur J Med Chem. 2016 Jun 10;115:14-25. doi: 10.1016/j.ejmech.2016.02.058. Epub 2016 Feb 27. Eur J Med Chem. 2016. PMID: 26991939 Free article.

5

Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.

Alder CM, Ambler M, Campbell AJ, Champigny AC, Deakin AM, Harling JD, Harris CA, Longstaff T, Lynn S, Maxwell AC, Mooney CJ, Scullion C, Singh OM, Smith IE, Somers DO, Tame CJ, Wayne G, Wilson C, Woolven JM. Alder CM, et al. ACS Med Chem Lett. 2013 Aug 12;4(10):948-52. doi: 10.1021/ml400206q. eCollection 2013 Oct 10. ACS Med Chem Lett. 2013. PMID: 24900590 Free PMC article.

6

Synthesis of a tetrasubstituted bicyclo [2.2.2] octane as a potential inhibitor of influenza virus sialidase.

Smith PW, Trivedi N, Howes PD, Sollis SL, Rahim G, Bethell RC, Lynn S. Smith PW, et al. Bioorg Med Chem Lett. 1999 Feb 22;9(4):611-4. doi: 10.1016/s0960-894x(99)00033-5. Bioorg Med Chem Lett. 1999. PMID: 10098674

7

Use of Calculated Physicochemical Properties to Enhance Quantitative Response When Using Charged Aerosol Detection.

Robinson MW, Hill AP, Readshaw SA, Hollerton JC, Upton RJ, Lynn SM, Besley SC, Boughtflower BJ. Robinson MW, et al. Among authors: lynn sm. Anal Chem. 2017 Feb 7;89(3):1772-1777. doi: 10.1021/acs.analchem.6b04060. Epub 2017 Jan 17. Anal Chem. 2017. PMID: 28095671

8

Isolation of translactone-containing triterpenes with thrombin inhibitory activities from the leaves of Lantana camara.

O'Neill MJ, Lewis JA, Noble HM, Holland S, Mansat C, Farthing JE, Foster G, Noble D, Lane SJ, Sidebottom PJ, Lynn SM, Hayes MV, Dix CJ. O'Neill MJ, et al. Among authors: lynn sm. J Nat Prod. 1998 Nov;61(11):1328-31. doi: 10.1021/np970464j. J Nat Prod. 1998. PMID: 9834145

9

NMR quantification using an artificial signal.

Farrant RD, Hollerton JC, Lynn SM, Provera S, Sidebottom PJ, Upton RJ. Farrant RD, et al. Among authors: lynn sm. Magn Reson Chem. 2010 Oct;48(10):753-62. doi: 10.1002/mrc.2647. Magn Reson Chem. 2010. PMID: 20803488

10

Novel stereocontrolled addition of allylmetal reagents to alpha-imino esters: efficient synthesis of chiral tetrahydroquinoline derivatives.

Fabio RD, Alvaro G, Bertani B, Donati D, Giacobbe S, Marchioro C, Palma C, Lynn SM. Fabio RD, et al. Among authors: lynn sm. J Org Chem. 2002 Oct 18;67(21):7319-28. doi: 10.1021/jo020327d. J Org Chem. 2002. PMID: 12375961

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