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Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
Barrett TN, Taylor JA, Barker D, Procopiou PA, Thompson JDF, Barrett J, Le J, Lynn SM, Pogany P, Pratley C, Pritchard JM, Roper JA, Rowedder JE, Slack RJ, Vitulli G, Macdonald SJF, Kerr WJ. Barrett TN, et al. Among authors: slack rj. J Med Chem. 2019 Aug 22;62(16):7543-7556. doi: 10.1021/acs.jmedchem.9b00819. Epub 2019 Aug 5. J Med Chem. 2019. PMID: 31381331 Free article.
The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.
Procopiou PA, Browning C, Buckley JM, Clark KL, Fechner L, Gore PM, Hancock AP, Hodgson ST, Holmes DS, Kranz M, Looker BE, Morriss KM, Parton DL, Russell LJ, Slack RJ, Sollis SL, Vile S, Watts CJ. Procopiou PA, et al. Among authors: slack rj. J Med Chem. 2011 Apr 14;54(7):2183-95. doi: 10.1021/jm1013874. Epub 2011 Mar 7. J Med Chem. 2011. PMID: 21381763
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.
Procopiou PA, Barrett JW, Barton NP, Begg M, Clapham D, Copley RC, Ford AJ, Graves RH, Hall DA, Hancock AP, Hill AP, Hobbs H, Hodgson ST, Jumeaux C, Lacroix YM, Miah AH, Morriss KM, Needham D, Sheriff EB, Slack RJ, Smith CE, Sollis SL, Staton H. Procopiou PA, et al. Among authors: slack rj. J Med Chem. 2013 Mar 14;56(5):1946-60. doi: 10.1021/jm301572h. Epub 2013 Feb 27. J Med Chem. 2013. PMID: 23409871
The discovery of quinoline based single-ligand human H1 and H3 receptor antagonists.
Procopiou PA, Ancliff RA, Gore PM, Hancock AP, Hodgson ST, Holmes DS, Keeling SP, Looker BE, Parr NA, Rowedder JE, Slack RJ. Procopiou PA, et al. Among authors: slack rj. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5855-5859. doi: 10.1016/j.bmcl.2016.11.022. Epub 2016 Nov 10. Bioorg Med Chem Lett. 2016. PMID: 27866818
Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis.
Procopiou PA, Ford AJ, Gore PM, Looker BE, Hodgson ST, Holmes DS, Vile S, Clark KL, Saunders KA, Slack RJ, Rowedder JE, Watts CJ. Procopiou PA, et al. Among authors: slack rj. ACS Med Chem Lett. 2017 Apr 21;8(5):577-581. doi: 10.1021/acsmedchemlett.7b00112. eCollection 2017 May 11. ACS Med Chem Lett. 2017. PMID: 28523114 Free PMC article.
53 results