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Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X. Eftekharzadeh B, et al. Nat Commun. 2019 Aug 8;10(1):3562. doi: 10.1038/s41467-019-11594-y. Nat Commun. 2019. PMID: 31395886 Free PMC article.
Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators.
De Mol E, Szulc E, Di Sanza C, Martínez-Cristóbal P, Bertoncini CW, Fenwick RB, Frigolé-Vivas M, Masín M, Hunter I, Buzón V, Brun-Heath I, García J, De Fabritiis G, Estébanez-Perpiñá E, McEwan IJ, Nebreda ÁR, Salvatella X. De Mol E, et al. Structure. 2018 Jan 2;26(1):145-152.e3. doi: 10.1016/j.str.2017.11.007. Epub 2017 Dec 7. Structure. 2018. PMID: 29225078 Free PMC article.
Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.
Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, García J, Nebreda ÁR, Gestwicki JE, Lieberman AP, Salvatella X. Eftekharzadeh B, et al. Nat Commun. 2019 Oct 7;10(1):4605. doi: 10.1038/s41467-019-12578-8. Nat Commun. 2019. PMID: 31591399 Free PMC article.
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway.
González L, Díaz L, Pous J, Baginski B, Duran-Corbera A, Scarpa M, Brun-Heath I, Igea A, Martin-Malpartida P, Ruiz L, Pallara C, Esguerra M, Colizzi F, Mayor-Ruiz C, Biondi RM, Soliva R, Macias MJ, Orozco M, Nebreda AR. González L, et al. Among authors: brun heath i. Nat Commun. 2023 Jun 12;14(1):3318. doi: 10.1038/s41467-023-39051-x. Nat Commun. 2023. PMID: 37308482 Free PMC article.
Rational optimization of a transcription factor activation domain inhibitor.
Basu S, Martínez-Cristóbal P, Frigolé-Vivas M, Pesarrodona M, Lewis M, Szulc E, Bañuelos CA, Sánchez-Zarzalejo C, Bielskutė S, Zhu J, Pombo-García K, Garcia-Cabau C, Zodi L, Dockx H, Smak J, Kaur H, Batlle C, Mateos B, Biesaga M, Escobedo A, Bardia L, Verdaguer X, Ruffoni A, Mawji NR, Wang J, Obst JK, Tam T, Brun-Heath I, Ventura S, Meierhofer D, García J, Robustelli P, Stracker TH, Sadar MD, Riera A, Hnisz D, Salvatella X. Basu S, et al. Among authors: brun heath i. Nat Struct Mol Biol. 2023 Dec;30(12):1958-1969. doi: 10.1038/s41594-023-01159-5. Epub 2023 Dec 4. Nat Struct Mol Biol. 2023. PMID: 38049566 Free PMC article.
Impact of DNA methylation on 3D genome structure.
Buitrago D, Labrador M, Arcon JP, Lema R, Flores O, Esteve-Codina A, Blanc J, Villegas N, Bellido D, Gut M, Dans PD, Heath SC, Gut IG, Brun Heath I, Orozco M. Buitrago D, et al. Nat Commun. 2021 May 28;12(1):3243. doi: 10.1038/s41467-021-23142-8. Nat Commun. 2021. PMID: 34050148 Free PMC article.
Bioactivity descriptors for uncharacterized chemical compounds.
Bertoni M, Duran-Frigola M, Badia-I-Mompel P, Pauls E, Orozco-Ruiz M, Guitart-Pla O, Alcalde V, Diaz VM, Berenguer-Llergo A, Brun-Heath I, Villegas N, de Herreros AG, Aloy P. Bertoni M, et al. Among authors: brun heath i. Nat Commun. 2021 Jun 24;12(1):3932. doi: 10.1038/s41467-021-24150-4. Nat Commun. 2021. PMID: 34168145 Free PMC article.
A multifunctional toolkit for target-directed cancer therapy.
Terrazas M , Sánchez D , Battistini F , Villegas N , Brun-Heath I , Orozco M . Terrazas M , et al. Chem Commun (Camb). 2019 Jan 15;55(6):802-805. doi: 10.1039/c8cc08823c. Chem Commun (Camb). 2019. PMID: 30574643
33 results