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The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition.
Parmar K, Kochupurakkal BS, Lazaro JB, Wang ZC, Palakurthi S, Kirschmeier PT, Yang C, Sambel LA, Färkkilä A, Reznichenko E, Reavis HD, Dunn CE, Zou L, Do KT, Konstantinopoulos PA, Matulonis UA, Liu JF, D'Andrea AD, Shapiro GI. Parmar K, et al. Clin Cancer Res. 2019 Oct 15;25(20):6127-6140. doi: 10.1158/1078-0432.CCR-19-0448. Epub 2019 Aug 13. Clin Cancer Res. 2019. PMID: 31409614 Free PMC article.
Mouse models of Fanconi anemia.
Parmar K, D'Andrea A, Niedernhofer LJ. Parmar K, et al. Mutat Res. 2009 Jul 31;668(1-2):133-40. doi: 10.1016/j.mrfmmm.2009.03.015. Epub 2009 Apr 10. Mutat Res. 2009. PMID: 19427003 Free PMC article. Review.
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Adelman CA, Lolo RL, Birkbak NJ, Murina O, Matsuzaki K, Horejsi Z, Parmar K, Borel V, Skehel JM, Stamp G, D'Andrea A, Sartori AA, Swanton C, Boulton SJ. Adelman CA, et al. Among authors: parmar k. Nature. 2013 Oct 17;502(7471):381-4. doi: 10.1038/nature12565. Epub 2013 Sep 4. Nature. 2013. PMID: 24005329 Free PMC article.
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.
Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, Parmar K. Mistry H, et al. Among authors: parmar k. Mol Cancer Ther. 2013 Dec;12(12):2651-62. doi: 10.1158/1535-7163.MCT-13-0103-T. Epub 2013 Oct 15. Mol Cancer Ther. 2013. PMID: 24130053 Free PMC article.
408 results