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Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites.
Matralis AN, Malik A, Penzo M, Moreno I, Almela MJ, Camino I, Crespo B, Saadeddin A, Ghidelli-Disse S, Rueda L, Calderon F, Osborne SA, Drewes G, Böesche M, Fernández-Álvaro E, Martin Hernando JI, Baker DA. Matralis AN, et al. Among authors: penzo m. J Med Chem. 2019 Oct 24;62(20):9217-9235. doi: 10.1021/acs.jmedchem.9b01099. Epub 2019 Oct 14. J Med Chem. 2019. PMID: 31566384 Free PMC article.
Cyclic nucleotide signalling in malaria parasites.
Baker DA, Drought LG, Flueck C, Nofal SD, Patel A, Penzo M, Walker EM. Baker DA, et al. Among authors: penzo m. Open Biol. 2017 Dec;7(12):170213. doi: 10.1098/rsob.170213. Open Biol. 2017. PMID: 29263246 Free PMC article. Review.
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Gemma S, Giovani S, Brindisi M, Tripaldi P, Brogi S, Savini L, Fiorini I, Novellino E, Butini S, Campiani G, Penzo M, Blackman MJ. Gemma S, et al. Among authors: penzo m. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5317-21. doi: 10.1016/j.bmcl.2012.06.023. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2012. PMID: 22796182
Rational design of the first difluorostatone-based PfSUB1 inhibitors.
Giovani S, Penzo M, Brogi S, Brindisi M, Gemma S, Novellino E, Savini L, Blackman MJ, Campiani G, Butini S. Giovani S, et al. Among authors: penzo m. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3582-6. doi: 10.1016/j.bmcl.2014.05.044. Epub 2014 May 23. Bioorg Med Chem Lett. 2014. PMID: 24909083
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.
Withers-Martinez C, Suarez C, Fulle S, Kher S, Penzo M, Ebejer JP, Koussis K, Hackett F, Jirgensons A, Finn P, Blackman MJ. Withers-Martinez C, et al. Among authors: penzo m. Int J Parasitol. 2012 May 15;42(6):597-612. doi: 10.1016/j.ijpara.2012.04.005. Epub 2012 Apr 27. Int J Parasitol. 2012. PMID: 22543039 Free PMC article.
97 results