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CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.
Egusquiaguirre SP, Liu S, Tošić I, Jiang K, Walker SR, Nicolais M, Saw TY, Xiang M, Bartel K, Nelson EA, Frank DA. Egusquiaguirre SP, et al. Among authors: nicolais m. Neoplasia. 2020 Jan;22(1):47-59. doi: 10.1016/j.neo.2019.10.002. Epub 2019 Nov 22. Neoplasia. 2020. PMID: 31765941 Free PMC article.
Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses.
Brown JR, Walker SR, Heppler LN, Tyekucheva S, Nelson EA, Klitgaard J, Nicolais M, Kroll Y, Xiang M, Yeh JE, Chaudhury M, Giaccone ZT, Fernandes SM, Jacobsen ED, Fisher DC, Freedman AS, Davids MS, Supko JG, Wu C, Frank DA. Brown JR, et al. Among authors: nicolais m. Am J Hematol. 2021 Apr 1;96(4):E95-E98. doi: 10.1002/ajh.26084. Epub 2021 Jan 11. Am J Hematol. 2021. PMID: 33373063 Free PMC article. Clinical Trial. No abstract available.
Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells.
Weisberg E, Liu Q, Zhang X, Nelson E, Sattler M, Liu F, Nicolais M, Zhang J, Mitsiades C, Smith RW, Stone R, Galinsky I, Nonami A, Griffin JD, Gray N. Weisberg E, et al. Among authors: nicolais m. PLoS One. 2013;8(2):e56473. doi: 10.1371/journal.pone.0056473. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437141 Free PMC article.