Tian S - Search Results

1

Structural optimization of aminopyrimidine-based CXCR4 antagonists.

Zhu F, Wang Y, Du Q, Ge W, Li Z, Wang X, Fu C, Luo L, Tian S, Ma H, Zheng J, Zhang Y, Sun X, He S, Zhang X. Zhu F, et al. Among authors: tian s. Eur J Med Chem. 2020 Feb 1;187:111914. doi: 10.1016/j.ejmech.2019.111914. Epub 2019 Nov 26. Eur J Med Chem. 2020. PMID: 31806538

2

Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors.

Yang Z, Ma H, Sun Z, Luo L, Tian S, Zheng J, Zhang X. Yang Z, et al. Among authors: tian s. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3665-70. doi: 10.1016/j.bmcl.2015.06.049. Epub 2015 Jun 18. Bioorg Med Chem Lett. 2015. PMID: 26119500

3

Identification of a New Series of Potent Adenosine A_2A Receptor Antagonists Based on 4-Amino-5-carbonitrile Pyrimidine Template for the Treatment of Parkinson's Disease.

Yang Z, Li L, Zheng J, Ma H, Tian S, Li J, Zhang H, Zhen X, Zhang X. Yang Z, et al. Among authors: tian s. ACS Chem Neurosci. 2016 Nov 16;7(11):1575-1584. doi: 10.1021/acschemneuro.6b00218. Epub 2016 Sep 9. ACS Chem Neurosci. 2016. PMID: 27569066

4

Discovery of Novel and Selective Adenosine A_2A Receptor Antagonists for Treating Parkinson's Disease through Comparative Structure-Based Virtual Screening.

Tian S, Wang X, Li L, Zhang X, Li Y, Zhu F, Hou T, Zhen X. Tian S, et al. J Chem Inf Model. 2017 Jun 26;57(6):1474-1487. doi: 10.1021/acs.jcim.7b00188. Epub 2017 May 15. J Chem Inf Model. 2017. PMID: 28463561

5

Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity.

Lu W, Liu Y, Ma H, Zheng J, Tian S, Sun Z, Luo L, Li J, Zhang H, Yang ZJ, Zhang X. Lu W, et al. Among authors: tian s. ACS Chem Neurosci. 2017 Sep 20;8(9):1980-1994. doi: 10.1021/acschemneuro.7b00153. Epub 2017 Jun 30. ACS Chem Neurosci. 2017. PMID: 28618224

6

Design, synthesis and fungicidal evaluation of novel pyraclostrobin analogues.

Wang L, Zhao S, Kong X, Cao L, Tian S, Ye Y, Qiao C. Wang L, et al. Among authors: tian s. Bioorg Med Chem. 2018 Feb 15;26(4):875-883. doi: 10.1016/j.bmc.2018.01.004. Epub 2018 Jan 10. Bioorg Med Chem. 2018. PMID: 29395803

7

Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.

Lu W, Zhang D, Ma H, Tian S, Zheng J, Wang Q, Luo L, Zhang X. Lu W, et al. Among authors: tian s. Eur J Med Chem. 2018 Jul 15;155:34-48. doi: 10.1016/j.ejmech.2018.05.035. Epub 2018 May 23. Eur J Med Chem. 2018. PMID: 29857275

8

Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo.

Pan P, Chen J, Li X, Li M, Yu H, Zhao JJ, Ni J, Wang X, Sun H, Tian S, Zhu F, Liu F, Huang Y, Hou T. Pan P, et al. Among authors: tian s. J Med Chem. 2018 Oct 11;61(19):8613-8624. doi: 10.1021/acs.jmedchem.8b00498. Epub 2018 Sep 27. J Med Chem. 2018. PMID: 30227711 Free PMC article.

9

Structural optimization on a virtual screening hit of smoothened receptor.

Song S, Jiang J, Zhao L, Wang Q, Lu W, Zheng C, Zhang J, Ma H, Tian S, Zheng J, Luo L, Li Y, Yang ZJ, Zhang X. Song S, et al. Among authors: tian s. Eur J Med Chem. 2019 Jun 15;172:1-15. doi: 10.1016/j.ejmech.2019.03.057. Epub 2019 Mar 26. Eur J Med Chem. 2019. PMID: 30939349

10

Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines.

Lin Y, Li Z, Ma H, Wang Y, Wang X, Song S, Zhao L, Wu S, Tian S, Fu C, Luo L, Zhu F, He S, Zheng J, Zhang X. Lin Y, et al. Among authors: tian s. ChemMedChem. 2020 Jul 3;15(13):1150-1162. doi: 10.1002/cmdc.202000268. Epub 2020 May 29. ChemMedChem. 2020. PMID: 32391652

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