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In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.
Osinski V, Bauknight DK, Dasa SSK, Harms MJ, Kroon T, Marshall MA, Garmey JC, Nguyen AT, Hartman J, Upadhye A, Srikakulapu P, Zhou A, O'Mahony G, Klibanov AL, Kelly KA, Boucher J, McNamara CA. Osinski V, et al. Among authors: boucher j. Theranostics. 2020 Jan 1;10(2):585-601. doi: 10.7150/thno.36572. eCollection 2020. Theranostics. 2020. PMID: 31903139 Free PMC article.
PPARγ and PPARα synergize to induce robust browning of white fat in vivo.
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, Ahnmark A, Nilsson D, Gennemark P, O'Mahony G, Osinski V, McNamara C, Boucher J. Kroon T, et al. Among authors: boucher j. Mol Metab. 2020 Jun;36:100964. doi: 10.1016/j.molmet.2020.02.007. Epub 2020 Feb 18. Mol Metab. 2020. PMID: 32248079 Free PMC article.
Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.
Khatib Shahidi R, M Hoffmann J, Hedjazifar S, Bonnet L, K Baboota R, Heasman S, Church C, Elias I, Bosch F, Boucher J, Hammarstedt A, Smith U. Khatib Shahidi R, et al. Among authors: boucher j. PLoS One. 2021 Feb 19;16(2):e0247300. doi: 10.1371/journal.pone.0247300. eCollection 2021. PLoS One. 2021. PMID: 33606810 Free PMC article.
776 results