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Page 1
ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development.
Magomedova L, Tiefenbach J, Zilberman E, Le Billan F, Voisin V, Saikali M, Boivin V, Robitaille M, Gueroussov S, Irimia M, Ray D, Patel R, Xu C, Jeyasuria P, Bader GD, Hughes TR, Morris QD, Scott MS, Krause H, Angers S, Blencowe BJ, Cummins CL. Magomedova L, et al. Nucleic Acids Res. 2019 Apr 8;47(6):2856-2870. doi: 10.1093/nar/gkz010. Nucleic Acids Res. 2019. PMID: 30698747 Free PMC article.
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.
Dotan I, Yang J, Ikeda J, Roth Z, Pollock-Tahiri E, Desai H, Sivasubramaniyam T, Rehal S, Rapps J, Li YZ, Le H, Farber G, Alchami E, Xiao C, Karim S, Gronda M, Saikali MF, Tirosh A, Wagner KU, Genest J, Schimmer AD, Gupta V, Minden MD, Cummins CL, Lewis GF, Robbins C, Jongstra-Bilen J, Cybulsky M, Woo M. Dotan I, et al. Among authors: saikali mf. Commun Biol. 2022 Feb 15;5(1):132. doi: 10.1038/s42003-022-03078-5. Commun Biol. 2022. PMID: 35169231 Free PMC article.
AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.
Gathercole LL, Nikolaou N, Harris SE, Arvaniti A, Poolman TM, Hazlehurst JM, Kratschmar DV, Todorčević M, Moolla A, Dempster N, Pink RC, Saikali MF, Bentley L, Penning TM, Ohlsson C, Cummins CL, Poutanen M, Odermatt A, Cox RD, Tomlinson JW. Gathercole LL, et al. Among authors: saikali mf. J Endocrinol. 2022 Apr 13;253(3):97-113. doi: 10.1530/JOE-21-0280. J Endocrinol. 2022. PMID: 35318963 Free PMC article.
Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death.
Arif W, Mathur B, Saikali MF, Chembazhi UV, Toohill K, Song YJ, Hao Q, Karimi S, Blue SM, Yee BA, Van Nostrand EL, Bangru S, Guzman G, Yeo GW, Prasanth KV, Anakk S, Cummins CL, Kalsotra A. Arif W, et al. Among authors: saikali mf. Nat Commun. 2023 Feb 9;14(1):551. doi: 10.1038/s41467-023-35932-3. Nat Commun. 2023. PMID: 36759613 Free PMC article.
A novel fatty acid mimetic with Pan-PPAR partial agonist activity inhibits diet-induced obesity and metabolic dysfunction-associated steatotic liver disease.
Sahin C, Melanson JR, Le Billan F, Magomedova L, Ferreira TAM, Oliveira AS, Pollock-Tahari E, Saikali MF, Cash SB, Woo M, Romeiro LAS, Cummins CL. Sahin C, et al. Among authors: saikali mf. Mol Metab. 2024 May 17:101958. doi: 10.1016/j.molmet.2024.101958. Online ahead of print. Mol Metab. 2024. PMID: 38763495 Free article.