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Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases.
Alvar J, Alves F, Bucheton B, Burrows L, Büscher P, Carrillo E, Felger I, Hübner MP, Moreno J, Pinazo MJ, Ribeiro I, Sosa-Estani S, Specht S, Tarral A, Wourgaft NS, Bilbe G. Alvar J, et al. Among authors: hubner mp. Semin Immunopathol. 2020 Jun;42(3):231-246. doi: 10.1007/s00281-020-00796-y. Epub 2020 Mar 18. Semin Immunopathol. 2020. PMID: 32189034 Free PMC article. Review.
ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance.
Ajendra J, Specht S, Neumann AL, Gondorf F, Schmidt D, Gentil K, Hoffmann WH, Taylor MJ, Hoerauf A, Hübner MP. Ajendra J, et al. Among authors: hubner mp. PLoS One. 2014 Mar 24;9(3):e93072. doi: 10.1371/journal.pone.0093072. eCollection 2014. PLoS One. 2014. PMID: 24663956 Free PMC article.
Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.
Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A. Specht S, et al. Among authors: hubner mp. PLoS Negl Trop Dis. 2018 Jan 4;12(1):e0006116. doi: 10.1371/journal.pntd.0006116. eCollection 2018 Jan. PLoS Negl Trop Dis. 2018. PMID: 29300732 Free PMC article.
Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
Hübner MP, Ehrens A, Koschel M, Dubben B, Lenz F, Frohberger SJ, Specht S, Quirynen L, Lachau-Durand S, Tekle F, Baeten B, Engelen M, Mackenzie CD, Hoerauf A. Hübner MP, et al. PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006320. doi: 10.1371/journal.pntd.0006320. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30650105 Free PMC article.
Filariasis research - from basic research to drug development and novel diagnostics, over a decade of research at the Institute for Medical Microbiology, Immunology and Parasitology, Bonn, Germany.
Karunakaran I, Ritter M, Pfarr K, Klarmann-Schulz U, Debrah AY, Debrah LB, Katawa G, Wanji S, Specht S, Adjobimey T, Hübner MP, Hoerauf A. Karunakaran I, et al. Among authors: hubner mp. Front Trop Dis. 2023 Mar 2;4:1126173. doi: 10.3389/fitd.2023.1126173. Front Trop Dis. 2023. PMID: 38655130 Free PMC article.
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
von Geldern TW, Morton HE, Clark RF, Brown BS, Johnston KL, Ford L, Specht S, Carr RA, Stolarik DF, Ma J, Rieser MJ, Struever D, Frohberger SJ, Koschel M, Ehrens A, Turner JD, Hübner MP, Hoerauf A, Taylor MJ, Ward SA, Marsh K, Kempf DJ. von Geldern TW, et al. Among authors: hubner mp. PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. doi: 10.1371/journal.pntd.0007159. eCollection 2019 Feb. PLoS Negl Trop Dis. 2019. PMID: 30818326 Free PMC article.
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