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Inhibition of the Yersinia pestis Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis by α-Phenyl-Substituted Reverse Fosmidomycin Analogues.
Ball HS, Girma M, Zainab M, Riley H, Behrendt CT, Lienau C, Konzuch S, Avelar LAA, Lungerich B, Soojhawon I, Noble SM, Kurz T, Couch RD. Ball HS, et al. Among authors: couch rd. ACS Omega. 2020 Mar 4;5(10):5170-5175. doi: 10.1021/acsomega.9b04171. eCollection 2020 Mar 17. ACS Omega. 2020. PMID: 32201804 Free PMC article.
Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.
San Jose G, Jackson ER, Haymond A, Johny C, Edwards RL, Wang X, Brothers RC, Edelstein EK, Odom AR, Boshoff HI, Couch RD, Dowd CS. San Jose G, et al. Among authors: couch rd. ACS Infect Dis. 2016 Dec 9;2(12):923-935. doi: 10.1021/acsinfecdis.6b00125. Epub 2016 Oct 12. ACS Infect Dis. 2016. PMID: 27676224 Free PMC article.
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.
Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: couch rd. J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24. J Med Chem. 2018. PMID: 30192536 Free PMC article.
MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase.
Wang X, Edwards RL, Ball HS, Heidel KM, Brothers RC, Johnson C, Haymond A, Girma M, Dailey A, Roma JS, Boshoff HI, Osbourn DM, Meyers MJ, Couch RD, Odom John AR, Dowd CS. Wang X, et al. Among authors: couch rd. ACS Infect Dis. 2023 Jul 14;9(7):1387-1395. doi: 10.1021/acsinfecdis.3c00132. Epub 2023 Jun 13. ACS Infect Dis. 2023. PMID: 37310810
Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).
Haymond A, Johny C, Dowdy T, Schweibenz B, Villarroel K, Young R, Mantooth CJ, Patel T, Bases J, San Jose G, Jackson ER, Dowd CS, Couch RD. Haymond A, et al. Among authors: couch rd. PLoS One. 2014 Aug 29;9(8):e106243. doi: 10.1371/journal.pone.0106243. eCollection 2014. PLoS One. 2014. PMID: 25171339 Free PMC article.
Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Chofor R, Sooriyaarachchi S, Risseeuw MD, Bergfors T, Pouyez J, Johny C, Haymond A, Everaert A, Dowd CS, Maes L, Coenye T, Alex A, Couch RD, Jones TA, Wouters J, Mowbray SL, Van Calenbergh S. Chofor R, et al. Among authors: couch rd. J Med Chem. 2015 Apr 9;58(7):2988-3001. doi: 10.1021/jm5014264. Epub 2015 Mar 31. J Med Chem. 2015. PMID: 25781377 Free article.
47 results