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Sigma-1 ligands: Tic-hydantoin as a key pharmacophore.
Toussaint M, Mousset D, Foulon C, Jacquemard U, Vaccher C, Melnyk P. Toussaint M, et al. Among authors: melnyk p. Eur J Med Chem. 2010 Jan;45(1):256-63. doi: 10.1016/j.ejmech.2009.10.004. Epub 2009 Oct 9. Eur J Med Chem. 2010. PMID: 19875205
Synthesis and Biological Evaluation of N-[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity.
Segaoula Z, Leclercq J, Verones V, Flouquet N, Lecoeur M, Ach L, Renault N, Barczyk A, Melnyk P, Berthelot P, Thuru X, Lebegue N. Segaoula Z, et al. Among authors: melnyk p. J Med Chem. 2016 Sep 22;59(18):8422-40. doi: 10.1021/acs.jmedchem.6b00847. Epub 2016 Aug 30. J Med Chem. 2016. PMID: 27538123 Free article.
Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.
Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P. Gibault F, et al. Among authors: melnyk p. Cancers (Basel). 2018 May 8;10(5):140. doi: 10.3390/cancers10050140. Cancers (Basel). 2018. PMID: 29738494 Free PMC article.
MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis.
Liberelle M, Magnez R, Thuru X, Bencheikh Y, Ravez S, Quenon C, Drucbert AS, Foulon C, Melnyk P, Van Seuningen I, Lebègue N. Liberelle M, et al. Among authors: melnyk p. Sci Rep. 2019 Nov 13;9(1):16678. doi: 10.1038/s41598-019-53099-0. Sci Rep. 2019. PMID: 31723153 Free PMC article.
Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists.
Hurtevent A, Le Naour M, Leclerc V, Carato P, Melnyk P, Hennuyer N, Staels B, Beucher-Gaudin M, Caignard DH, Dacquet C, Lebegue N. Hurtevent A, et al. Among authors: melnyk p. J Enzyme Inhib Med Chem. 2020 Dec;35(1):524-538. doi: 10.1080/14756366.2020.1713771. J Enzyme Inhib Med Chem. 2020. PMID: 31939313 Free PMC article.
101 results