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The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia.
Losson H, Gajulapalli SR, Lernoux M, Lee JY, Mazumder A, Gérard D, Seidel C, Hahn H, Christov C, Dicato M, Kirsch G, Han BW, Schnekenburger M, Diederich M. Losson H, et al. Among authors: kirsch g. Pharmacol Res. 2020 Oct;160:105058. doi: 10.1016/j.phrs.2020.105058. Epub 2020 Jun 30. Pharmacol Res. 2020. PMID: 32619722
Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.
Valente S, Liu Y, Schnekenburger M, Zwergel C, Cosconati S, Gros C, Tardugno M, Labella D, Florean C, Minden S, Hashimoto H, Chang Y, Zhang X, Kirsch G, Novellino E, Arimondo PB, Miele E, Ferretti E, Gulino A, Diederich M, Cheng X, Mai A. Valente S, et al. Among authors: kirsch g. J Med Chem. 2014 Feb 13;57(3):701-13. doi: 10.1021/jm4012627. Epub 2014 Jan 15. J Med Chem. 2014. PMID: 24387159 Free PMC article.
Synthesis and bioactivity of novel amino-pyrazolopyridines.
Orlikova B, Chaouni W, Schumacher M, Aadil M, Diederich M, Kirsch G. Orlikova B, et al. Among authors: kirsch g. Eur J Med Chem. 2014 Oct 6;85:450-7. doi: 10.1016/j.ejmech.2014.08.008. Epub 2014 Aug 5. Eur J Med Chem. 2014. PMID: 25108361
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.
Zwergel C, Czepukojc B, Evain-Bana E, Xu Z, Stazi G, Mori M, Patsilinakos A, Mai A, Botta B, Ragno R, Bagrel D, Kirsch G, Meiser P, Jacob C, Montenarh M, Valente S. Zwergel C, et al. Among authors: kirsch g. Eur J Med Chem. 2017 Jul 7;134:316-333. doi: 10.1016/j.ejmech.2017.04.012. Epub 2017 Apr 10. Eur J Med Chem. 2017. PMID: 28431339
194 results