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PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.
Breasson L, Sardi C, Becattini B, Zani F, Solinas G. Breasson L, et al. Among authors: solinas g. FASEB J. 2018 Jan;32(1):319-329. doi: 10.1096/fj.201700372RR. Epub 2017 Sep 13. FASEB J. 2018. PMID: 28904022
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects on insulin secretion.-Breasson, L., Sardi, C., Becattini, B., Zani, F., Solinas, G. PI3Kgamma ablation does not promote diabet …
We conclude that PI3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to produce adverse effects …
The role of PI3Kγ in metabolism and macrophage activation.
Solinas G, Becattini B. Solinas G, et al. Oncotarget. 2017 Oct 25;8(63):106145-106146. doi: 10.18632/oncotarget.22068. eCollection 2017 Dec 5. Oncotarget. 2017. PMID: 29290924 Free PMC article. No abstract available.
159 results