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Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms.
Biochem Pharmacol. 2020 Dec;182:114213. doi: 10.1016/j.bcp.2020.114213. Epub 2020 Sep 3.
Biochem Pharmacol. 2020.
PMID: 32890467
Review.
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose.
Defenouillère Q, Verraes A, Laussel C, Friedrich A, Schacherer J, Léon S.
Defenouillère Q, et al. Among authors: laussel c.
Sci Signal. 2019 Sep 3;12(597):eaaw8000. doi: 10.1126/scisignal.aaw8000.
Sci Signal. 2019.
PMID: 31481524
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2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity.
Laussel C, Albanèse V, García-Rodríguez FJ, Ballin A, Defenouillère Q, Léon S.
Laussel C, et al.
PLoS Genet. 2022 Aug 11;18(8):e1010169. doi: 10.1371/journal.pgen.1010169. eCollection 2022 Aug.
PLoS Genet. 2022.
PMID: 35951639
Free PMC article.
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