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Two to tango! IL-13 and TGF-β drive myelofibrosis.
Jutzi JS, Mullally A. Jutzi JS, et al. Blood. 2022 Dec 29;140(26):2767-2768. doi: 10.1182/blood.2022018859. Blood. 2022. PMID: 36580345 Free PMC article. No abstract available.
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.
Jutzi JS, Bogeska R, Nikoloski G, Schmid CA, Seeger TS, Stegelmann F, Schwemmers S, Gründer A, Peeken JC, Gothwal M, Wehrle J, Aumann K, Hamdi K, Dierks C, Kamar Wang W, Döhner K, Jansen JH, Pahl HL. Jutzi JS, et al. J Exp Med. 2013 May 6;210(5):1003-19. doi: 10.1084/jem.20120521. J Exp Med. 2013. PMID: 23589569 Free PMC article.
Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both.
Koschmieder S, Mughal TI, Hasselbalch HC, Barosi G, Valent P, Kiladjian JJ, Jeryczynski G, Gisslinger H, Jutzi JS, Pahl HL, Hehlmann R, Maria Vannucchi A, Cervantes F, Silver RT, Barbui T. Koschmieder S, et al. Among authors: jutzi js. Leukemia. 2016 May;30(5):1018-24. doi: 10.1038/leu.2016.12. Epub 2016 Feb 8. Leukemia. 2016. PMID: 26854026 Review.
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.
Prestipino A, Emhardt AJ, Aumann K, O'Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi JS, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel FH, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, von Bubnoff N, Pearce EL, Zeiser R. Prestipino A, et al. Among authors: jutzi js. Sci Transl Med. 2018 Feb 21;10(429):eaam7729. doi: 10.1126/scitranslmed.aam7729. Sci Transl Med. 2018. PMID: 29467301 Free PMC article.
Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.
Peeken JC, Jutzi JS, Wehrle J, Koellerer C, Staehle HF, Becker H, Schoenwandt E, Seeger TS, Schanne DH, Gothwal M, Ott CJ, Gründer A, Pahl HL. Peeken JC, et al. Among authors: jutzi js. Blood. 2018 May 3;131(18):2065-2073. doi: 10.1182/blood-2017-10-810622. Epub 2018 Mar 8. Blood. 2018. PMID: 29519804 Free PMC article.
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