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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, Komoly S, Houdusse A, Málnási-Csizmadia A. Gyimesi M, et al. Among authors: houdusse a. Cell. 2020 Oct 15;183(2):335-346.e13. doi: 10.1016/j.cell.2020.08.050. Epub 2020 Oct 8. Cell. 2020. PMID: 33035452 Free PMC article.
How actin initiates the motor activity of Myosin.
Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A. Llinas P, et al. Among authors: houdusse a. Dev Cell. 2015 May 26;33(4):401-12. doi: 10.1016/j.devcel.2015.03.025. Epub 2015 Apr 30. Dev Cell. 2015. PMID: 25936506 Free PMC article.
Myosin 7 and its adaptors link cadherins to actin.
Yu IM, Planelles-Herrero VJ, Sourigues Y, Moussaoui D, Sirkia H, Kikuti C, Stroebel D, Titus MA, Houdusse A. Yu IM, et al. Among authors: houdusse a. Nat Commun. 2017 Jun 29;8:15864. doi: 10.1038/ncomms15864. Nat Commun. 2017. PMID: 28660889 Free PMC article.
Optimized filopodia formation requires myosin tail domain cooperation.
Arthur AL, Songster LD, Sirkia H, Bhattacharya A, Kikuti C, Borrega FP, Houdusse A, Titus MA. Arthur AL, et al. Among authors: houdusse a. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22196-22204. doi: 10.1073/pnas.1901527116. Epub 2019 Oct 14. Proc Natl Acad Sci U S A. 2019. PMID: 31611382 Free PMC article.
Force Generation by Myosin Motors: A Structural Perspective.
Robert-Paganin J, Pylypenko O, Kikuti C, Sweeney HL, Houdusse A. Robert-Paganin J, et al. Among authors: houdusse a. Chem Rev. 2020 Jan 8;120(1):5-35. doi: 10.1021/acs.chemrev.9b00264. Epub 2019 Nov 5. Chem Rev. 2020. PMID: 31689091 Review.
Cryo-EM structure of the folded-back state of human β-cardiac myosin.
Grinzato A, Auguin D, Kikuti C, Nandwani N, Moussaoui D, Pathak D, Kandiah E, Ruppel KM, Spudich JA, Houdusse A, Robert-Paganin J. Grinzato A, et al. Among authors: houdusse a. Nat Commun. 2023 May 31;14(1):3166. doi: 10.1038/s41467-023-38698-w. Nat Commun. 2023. PMID: 37258552 Free PMC article.
Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6.
Ranaivoson FM, Crozet V, Benoit MPMH, Abdalla Mohammed Khalid A, Kikuti C, Sirkia H, El Marjou A, Miserey-Lenkei S, Asenjo AB, Sosa H, Schmidt CF, Rosenfeld SS, Houdusse A. Ranaivoson FM, et al. Among authors: houdusse a. Open Biol. 2023 Sep;13(9):230122. doi: 10.1098/rsob.230122. Epub 2023 Sep 20. Open Biol. 2023. PMID: 37726093 Free PMC article.
107 results