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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Gyimesi M, Horváth ÁI, Túrós D, Suthar SK, Pénzes M, Kurdi C, Canon L, Kikuti C, Ruppel KM, Trivedi DV, Spudich JA, Lőrincz I, Rauscher AÁ, Kovács M, Pál E, Komoly S, Houdusse A, Málnási-Csizmadia A. Gyimesi M, et al. Among authors: trivedi dv. Cell. 2020 Oct 15;183(2):335-346.e13. doi: 10.1016/j.cell.2020.08.050. Epub 2020 Oct 8. Cell. 2020. PMID: 33035452 Free PMC article.
Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Anderson RL, Trivedi DV, Sarkar SS, Henze M, Ma W, Gong H, Rogers CS, Gorham JM, Wong FL, Morck MM, Seidman JG, Ruppel KM, Irving TC, Cooke R, Green EM, Spudich JA. Anderson RL, et al. Among authors: trivedi dv. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8143-E8152. doi: 10.1073/pnas.1809540115. Epub 2018 Aug 13. Proc Natl Acad Sci U S A. 2018. PMID: 30104387 Free PMC article.
Magnesium modulates actin binding and ADP release in myosin motors.
Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM. Swenson AM, et al. Among authors: trivedi dv. J Biol Chem. 2014 Aug 22;289(34):23977-91. doi: 10.1074/jbc.M114.562231. Epub 2014 Jul 8. J Biol Chem. 2014. PMID: 25006251 Free PMC article.
SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O. Wilkinson AW, et al. Among authors: trivedi dv. Nature. 2019 Jan;565(7739):372-376. doi: 10.1038/s41586-018-0821-8. Epub 2018 Dec 10. Nature. 2019. PMID: 30626964 Free PMC article.
26 results