Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.
Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS.
Haggie PM, et al.
FASEB J. 2016 Jun;30(6):2187-97. doi: 10.1096/fj.201600223R. Epub 2016 Mar 1.
FASEB J. 2016.
PMID: 26932931
Free PMC article.
These studies implicate the involvement of pendrin-facilitated Cl(-)/HCO3 (-) in the regulation of ASL volume and suggest the utility of pendrin inhibitors in inflammatory lung diseases, including CF.-Haggie, P. M., Phuan, P.-W., Tan, J.-A., Zlock, L., Finkbeiner, …
These studies implicate the involvement of pendrin-facilitated Cl(-)/HCO3 (-) in the regulation of ASL volume and suggest the utility of pen …