Duncton MAJ - Search Results

1

Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.

Wilson DM 3rd, Deacon AM, Duncton MAJ, Pellicena P, Georgiadis MM, Yeh AP, Arvai AS, Moiani D, Tainer JA, Das D. Wilson DM 3rd, et al. Among authors: duncton maj. Prog Biophys Mol Biol. 2021 Aug;163:130-142. doi: 10.1016/j.pbiomolbio.2020.10.005. Epub 2020 Oct 25. Prog Biophys Mol Biol. 2021. PMID: 33115610 Free PMC article.

2

Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH).

Wilson DM, Duncton MAJ, Chang C, Lee Luo C, Georgiadis TM, Pellicena P, Deacon AM, Gao Y, Das D. Wilson DM, et al. Among authors: duncton maj. Front Oncol. 2021 Nov 19;11:778925. doi: 10.3389/fonc.2021.778925. eCollection 2021. Front Oncol. 2021. PMID: 34900730 Free PMC article.

3

Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy.

Markovtsov V, Duncton MAJ, Bagos A, Yi S, Braselmann S, Bhamidipati S, Darwish IS, Yu J, Owyang AM, Fernandez B, Samant B, Park G, Masuda ES, Shaw SJ. Markovtsov V, et al. Among authors: duncton maj. ACS Med Chem Lett. 2023 Nov 21;14(12):1700-1706. doi: 10.1021/acsmedchemlett.3c00336. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116420

4

A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1.

Das D, Duncton MAJ, Georgiadis TM, Pellicena P, Clark J, Sobol RW, Georgiadis MM, King-Underwood J, Jobes DV, Chang C, Gao Y, Deacon AM, Wilson DM 3rd. Das D, et al. Among authors: duncton maj. Int J Mol Sci. 2023 Nov 23;24(23):16637. doi: 10.3390/ijms242316637. Int J Mol Sci. 2023. PMID: 38068959 Free PMC article.

5

Development of a MEK inhibitor, NFX-179, as a chemoprevention agent for squamous cell carcinoma.

Sarin KY, Kincaid J, Sell B, Shahryari J, Duncton MAJ, Morefield E, Sun W, Prieto K, Chavez-Chiang O, de Moran Segura C, Nguyen J, Bronson RT, Plotkin SR, Kochendoerfer GG, Fenn P, Wootton MA, Powala C, de Souza MP, Tsai KY. Sarin KY, et al. Among authors: duncton maj. Sci Transl Med. 2023 Oct 11;15(717):eade1844. doi: 10.1126/scitranslmed.ade1844. Epub 2023 Oct 11. Sci Transl Med. 2023. PMID: 37820007

6

A Single-Step Synthesis of Azetidine-3-amines.

Wang BJ, Duncton MAJ. Wang BJ, et al. Among authors: duncton maj. J Org Chem. 2020 Oct 16;85(20):13317-13323. doi: 10.1021/acs.joc.0c01831. Epub 2020 Sep 29. J Org Chem. 2020. PMID: 32931702

7

Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.

Gordon EM, Duncton MAJ, Wang BJ, Qi L, Fan D, Li X, Ni ZJ, Ding P, Grygorash R, Low E, Yu G, Sun J. Gordon EM, et al. Among authors: duncton maj. ACS Med Chem Lett. 2020 Jan 8;11(2):162-165. doi: 10.1021/acsmedchemlett.9b00534. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071683 Free PMC article.

8

Orally Absorbed Derivatives of the β-Lactamase Inhibitor Avibactam. Design of Novel Prodrugs of Sulfate Containing Drugs.

Gordon EM, Duncton MAJ, Gallop MA. Gordon EM, et al. Among authors: duncton maj. J Med Chem. 2018 Nov 21;61(22):10340-10344. doi: 10.1021/acs.jmedchem.8b01389. Epub 2018 Nov 3. J Med Chem. 2018. PMID: 30296086

9

Enantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution.

Zhang J, Kolluri R, Alvarez SG, Irving MM, Singh R, Duncton MA. Zhang J, et al. Org Biomol Chem. 2017 Apr 5;15(14):2953-2961. doi: 10.1039/c7ob00192d. Org Biomol Chem. 2017. PMID: 28291271

10

Tetrazolone as an acid bioisostere: application to marketed drugs containing a carboxylic acid.

Duncton MA, Murray RB, Park G, Singh R. Duncton MA, et al. Org Biomol Chem. 2016 Oct 4;14(39):9343-9347. doi: 10.1039/c6ob01646d. Org Biomol Chem. 2016. PMID: 27714239

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