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The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.
Lebeau PF, Wassef H, Byun JH, Platko K, Ason B, Jackson S, Dobroff J, Shetterly S, Richards WG, Al-Hashimi AA, Won KD, Mbikay M, Prat A, Tang A, Paré G, Pasqualini R, Seidah NG, Arap W, Chrétien M, Austin RC. Lebeau PF, et al. Among authors: byun jh. J Clin Invest. 2021 Jan 19;131(2):e128650. doi: 10.1172/JCI128650. J Clin Invest. 2021. PMID: 33211673 Free PMC article.
Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.
Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC. Lebeau P, et al. Among authors: byun jh. J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28. J Biol Chem. 2018. PMID: 29593095 Free PMC article.
Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.
Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhoták Š, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchiò S, Pasqualini R, Arap W, Austin RC. Crane ED, et al. Among authors: byun jh. JCI Insight. 2018 Dec 20;3(24):e99363. doi: 10.1172/jci.insight.99363. JCI Insight. 2018. PMID: 30568038 Free PMC article.
GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury.
Platko K, Lebeau PF, Byun JH, Poon SV, Day EA, MacDonald ME, Holzapfel N, Mejia-Benitez A, Maclean KN, Krepinsky JC, Austin RC. Platko K, et al. Among authors: byun jh. Mol Metab. 2019 Sep;27:62-74. doi: 10.1016/j.molmet.2019.06.021. Epub 2019 Jun 28. Mol Metab. 2019. PMID: 31288993 Free PMC article.
529 results