Chrétien M - Search Results

1

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.

Lebeau PF, Wassef H, Byun JH, Platko K, Ason B, Jackson S, Dobroff J, Shetterly S, Richards WG, Al-Hashimi AA, Won KD, Mbikay M, Prat A, Tang A, Paré G, Pasqualini R, Seidah NG, Arap W, Chrétien M, Austin RC. Lebeau PF, et al. Among authors: chretien m. J Clin Invest. 2021 Jan 19;131(2):e128650. doi: 10.1172/JCI128650. J Clin Invest. 2021. PMID: 33211673 Free PMC article.

2

The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.

Seidah NG, Chrétien M, Mbikay M. Seidah NG, et al. Among authors: chretien m. Curr Opin Lipidol. 2018 Apr;29(2):144-150. doi: 10.1097/MOL.0000000000000484. Curr Opin Lipidol. 2018. PMID: 29342010 Review.

3

Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms.

Mbikay M, Mayne J, Seidah NG, Chrétien M. Mbikay M, et al. Among authors: chretien m. Med Hypotheses. 2007;69(5):1010-7. doi: 10.1016/j.mehy.2007.03.018. Epub 2007 May 14. Med Hypotheses. 2007. PMID: 17502126

4

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M. Mayne J, et al. Among authors: chretien m. Clin Chem. 2011 Oct;57(10):1415-23. doi: 10.1373/clinchem.2011.165191. Epub 2011 Aug 3. Clin Chem. 2011. PMID: 21813713

5

PCSK9: a key modulator of cardiovascular health.

Seidah NG, Awan Z, Chrétien M, Mbikay M. Seidah NG, et al. Among authors: chretien m. Circ Res. 2014 Mar 14;114(6):1022-36. doi: 10.1161/CIRCRESAHA.114.301621. Circ Res. 2014. PMID: 24625727 Review.

6

Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function.

Mayne J, Ooi TC, Tepliakova L, Seebun D, Walker K, Mohottalage D, Ning Z, Abujrad H, Mbikay M, Wassef H, Chrétien M, Figeys D. Mayne J, et al. Among authors: chretien m. J Clin Endocrinol Metab. 2018 Sep 1;103(9):3486-3495. doi: 10.1210/jc.2018-00777. J Clin Endocrinol Metab. 2018. PMID: 29982529

7

The biological relevance of PCSK9: when less is better….

Mbikay M, Chrétien M. Mbikay M, et al. Among authors: chretien m. Biochem Cell Biol. 2022 Jun 1;100(3):189-198. doi: 10.1139/bcb-2021-0540. Epub 2022 Mar 9. Biochem Cell Biol. 2022. PMID: 35263196 Free article. Review.

8

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM. Siegfried G, et al. Among authors: chretien m. J Clin Invest. 2003 Jun;111(11):1723-32. doi: 10.1172/JCI17220. J Clin Invest. 2003. PMID: 12782675 Free PMC article.

9

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

Salvas A, Benjannet S, Reudelhuber TL, Chrétien M, Seidah NG. Salvas A, et al. Among authors: chretien m. FEBS Lett. 2005 Oct 24;579(25):5621-5. doi: 10.1016/j.febslet.2005.09.029. Epub 2005 Sep 28. FEBS Lett. 2005. PMID: 16213495 Free article.

10

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.

Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A. Essalmani R, et al. Among authors: chretien m. Mol Cell Biol. 2006 Jan;26(1):354-61. doi: 10.1128/MCB.26.1.354-361.2006. Mol Cell Biol. 2006. PMID: 16354705 Free PMC article.

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