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The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32145-32154. doi: 10.1073/pnas.2009680117. Epub 2020 Nov 30.
Proc Natl Acad Sci U S A. 2020.
PMID: 33257576
Free PMC article.
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.
Marchetti C, et al. Among authors: skouras db.
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539. doi: 10.1073/pnas.1716095115. Epub 2018 Jan 29.
Proc Natl Acad Sci U S A. 2018.
PMID: 29378952
Free PMC article.
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OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.
Sánchez-Fernández A, Skouras DB, Dinarello CA, López-Vales R.
Sánchez-Fernández A, et al. Among authors: skouras db.
Front Immunol. 2019 Nov 1;10:2578. doi: 10.3389/fimmu.2019.02578. eCollection 2019.
Front Immunol. 2019.
PMID: 31736980
Free PMC article.
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Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury.
Amo-Aparicio J, Garcia-Garcia J, Puigdomenech M, Francos-Quijorna I, Skouras DB, Dinarello CA, Lopez-Vales R.
Amo-Aparicio J, et al. Among authors: skouras db.
Exp Neurol. 2022 Jan;347:113889. doi: 10.1016/j.expneurol.2021.113889. Epub 2021 Oct 12.
Exp Neurol. 2022.
PMID: 34624330
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Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
Klück V, Jansen TLTA, Janssen M, Comarniceanu A, Efdé M, Tengesdal IW, Schraa K, Cleophas MCP, Scribner CL, Skouras DB, Marchetti C, Dinarello CA, Joosten LAB.
Klück V, et al. Among authors: skouras db.
Lancet Rheumatol. 2020 May;2(5):e270-e280. doi: 10.1016/s2665-9913(20)30065-5. Epub 2020 Apr 8.
Lancet Rheumatol. 2020.
PMID: 33005902
Free PMC article.
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The NLRP3 inflammasome inhibitor, OLT1177® , ameliorates experimental allergic asthma in mice.
Lunding LP, Skouras DB, Vock C, Dinarello CA, Wegmann M.
Lunding LP, et al. Among authors: skouras db.
Allergy. 2022 Mar;77(3):1035-1038. doi: 10.1111/all.15164. Epub 2021 Nov 10.
Allergy. 2022.
PMID: 34716997
No abstract available.
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