Heimbach T - Search Results

1

Physiologically-Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective.

Heimbach T, Chen Y, Chen J, Dixit V, Parrott N, Peters SA, Poggesi I, Sharma P, Snoeys J, Shebley M, Tai G, Tse S, Upreti VV, Wang YH, Tsai A, Xia B, Zheng M, Zhu AZX, Hall S. Heimbach T, et al. Clin Pharmacol Ther. 2021 Aug;110(2):297-310. doi: 10.1002/cpt.2125. Epub 2020 Dec 30. Clin Pharmacol Ther. 2021. PMID: 33270249 Free PMC article.

2

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions.

Xia B, Heimbach T, Lin TH, He H, Wang Y, Tan E. Xia B, et al. Among authors: heimbach t. Cancer Chemother Pharmacol. 2012 Jun;69(6):1567-82. doi: 10.1007/s00280-012-1863-5. Epub 2012 Apr 11. Cancer Chemother Pharmacol. 2012. PMID: 22526410

3

Nilotinib preclinical pharmacokinetics and practical application toward clinical projections of oral absorption and systemic availability.

Xia B, Heimbach T, He H, Lin TH. Xia B, et al. Among authors: heimbach t. Biopharm Drug Dispos. 2012 Dec;33(9):536-49. doi: 10.1002/bdd.1821. Epub 2012 Nov 19. Biopharm Drug Dispos. 2012. PMID: 23097199

4

Case studies for practical food effect assessments across BCS/BDDCS class compounds using in silico, in vitro, and preclinical in vivo data.

Heimbach T, Xia B, Lin TH, He H. Heimbach T, et al. AAPS J. 2013 Jan;15(1):143-58. doi: 10.1208/s12248-012-9419-5. Epub 2012 Nov 10. AAPS J. 2013. PMID: 23139017 Free PMC article.

5

A simplified PBPK modeling approach for prediction of pharmacokinetics of four primarily renally excreted and CYP3A metabolized compounds during pregnancy.

Xia B, Heimbach T, Gollen R, Nanavati C, He H. Xia B, et al. Among authors: heimbach t. AAPS J. 2013 Oct;15(4):1012-24. doi: 10.1208/s12248-013-9505-3. Epub 2013 Jul 9. AAPS J. 2013. PMID: 23835676 Free PMC article.

6

Utility of physiologically based modeling and preclinical in vitro/in vivo data to mitigate positive food effect in a BCS class 2 compound.

Xia B, Heimbach T, Lin TH, Li S, Zhang H, Sheng J, He H. Xia B, et al. Among authors: heimbach t. AAPS PharmSciTech. 2013 Sep;14(3):1255-66. doi: 10.1208/s12249-013-0018-2. Epub 2013 Aug 17. AAPS PharmSciTech. 2013. PMID: 23955148 Free PMC article. Clinical Trial.

7

Application of physiologically based absorption modeling to formulation development of a low solubility, low permeability weak base: mechanistic investigation of food effect.

Zhang H, Xia B, Sheng J, Heimbach T, Lin TH, He H, Wang Y, Novick S, Comfort A. Zhang H, et al. Among authors: heimbach t. AAPS PharmSciTech. 2014 Apr;15(2):400-6. doi: 10.1208/s12249-014-0075-1. Epub 2014 Jan 17. AAPS PharmSciTech. 2014. PMID: 24435225 Free PMC article.

8

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

Xia B, Barve A, Heimbach T, Zhang T, Gu H, Wang L, Einolf H, Alexander N, Hanna I, Ke J, Mangold JB, He H, Sunkara G. Xia B, et al. Among authors: heimbach t. Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4. Eur J Pharm Sci. 2014. PMID: 25008118

9

Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape.

Schuck E, Bohnert T, Chakravarty A, Damian-Iordache V, Gibson C, Hsu CP, Heimbach T, Krishnatry AS, Liederer BM, Lin J, Maurer T, Mettetal JT, Mudra DR, Nijsen MJ, Raybon J, Schroeder P, Schuck V, Suryawanshi S, Su Y, Trapa P, Tsai A, Vakilynejad M, Wang S, Wong H. Schuck E, et al. Among authors: heimbach t. AAPS J. 2015 Mar;17(2):462-73. doi: 10.1208/s12248-014-9716-2. Epub 2015 Jan 29. AAPS J. 2015. PMID: 25630504 Free PMC article.

10

Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective.

Jones HM, Chen Y, Gibson C, Heimbach T, Parrott N, Peters SA, Snoeys J, Upreti VV, Zheng M, Hall SD. Jones HM, et al. Among authors: heimbach t. Clin Pharmacol Ther. 2015 Mar;97(3):247-62. doi: 10.1002/cpt.37. Epub 2015 Jan 9. Clin Pharmacol Ther. 2015. PMID: 25670209 Review.

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