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In situ genome sequencing resolves DNA sequence and structure in intact biological samples.
Payne AC, Chiang ZD, Reginato PL, Mangiameli SM, Murray EM, Yao CC, Markoulaki S, Earl AS, Labade AS, Jaenisch R, Church GM, Boyden ES, Buenrostro JD, Chen F. Payne AC, et al. Among authors: chiang zd. Science. 2021 Feb 26;371(6532):eaay3446. doi: 10.1126/science.aay3446. Epub 2020 Dec 31. Science. 2021. PMID: 33384301 Free PMC article.
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.
LaFave LM, Kartha VK, Ma S, Meli K, Del Priore I, Lareau C, Naranjo S, Westcott PMK, Duarte FM, Sankar V, Chiang Z, Brack A, Law T, Hauck H, Okimoto A, Regev A, Buenrostro JD, Jacks T. LaFave LM, et al. Cancer Cell. 2020 Aug 10;38(2):212-228.e13. doi: 10.1016/j.ccell.2020.06.006. Epub 2020 Jul 23. Cancer Cell. 2020. PMID: 32707078 Free PMC article.
Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling.
Lareau CA, Ludwig LS, Muus C, Gohil SH, Zhao T, Chiang Z, Pelka K, Verboon JM, Luo W, Christian E, Rosebrock D, Getz G, Boland GM, Chen F, Buenrostro JD, Hacohen N, Wu CJ, Aryee MJ, Regev A, Sankaran VG. Lareau CA, et al. Nat Biotechnol. 2021 Apr;39(4):451-461. doi: 10.1038/s41587-020-0645-6. Epub 2020 Aug 12. Nat Biotechnol. 2021. PMID: 32788668 Free PMC article.
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.
Zhao T, Chiang ZD, Morriss JW, LaFave LM, Murray EM, Del Priore I, Meli K, Lareau CA, Nadaf NM, Li J, Earl AS, Macosko EZ, Jacks T, Buenrostro JD, Chen F. Zhao T, et al. Among authors: chiang zd. Nature. 2022 Jan;601(7891):85-91. doi: 10.1038/s41586-021-04217-4. Epub 2021 Dec 15. Nature. 2022. PMID: 34912115 Free PMC article.